Coagulation abnormalities and thrombosis in patients infected with SARS-CoV-2 and other pandemic viruses

N Mackman, S Antoniak, AS Wolberg… - … , and vascular biology, 2020 - Am Heart Assoc
The world is amid a pandemic caused by severe acute respiratory syndrome-coronavirus 2.
Severe acute respiratory syndrome-coronavirus causes serious respiratory tract infections …

Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19

RB Polidoro, RS Hagan, R de Santis Santiago… - Frontiers in …, 2020 - frontiersin.org
Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

CP Sodhi, C Wohlford-Lenane… - … of Physiology-Lung …, 2018 - journals.physiology.org
Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase with important
functions in the renin-angiotensin system and plays a critical role in inflammatory lung …

SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy

MK Chung, S Karnik, J Saef, C Bergmann, J Barnard… - …, 2020 - thelancet.com
Background SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-
converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or …

Pulmonary angiotensin-converting enzyme 2 (ACE2) and inflammatory lung disease

H Jia - Shock, 2016 - journals.lww.com
In response to infectious and, in some instances, noninfectious insults, the affected
tissues/cells of the host undergo inflammation. However, uncontrolled inflammation could be …

[HTML][HTML] The role of saliva in tick feeding

IMB Francischetti, A Sa-Nunes, BJ Mans… - … in bioscience: a …, 2009 - ncbi.nlm.nih.gov
When attempting to feed on their hosts, ticks face the problem of host hemostasis (the
vertebrate mechanisms that prevent blood loss), inflammation (that can produce itching or …

Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing

P Baumert, MJ Lake, CE Stewart, B Drust… - European journal of …, 2016 - Springer
Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can
result in ultrastructural muscle disruption, impaired excitation–contraction coupling …

Immunological mechanisms in the pathogenesis of diabetic retinopathy

AP Adamis, AJ Berman - Seminars in immunopathology, 2008 - Springer
There is an accumulating body of evidence that immunological mechanisms play a
prominent role in the pathogenesis of diabetic retinopathy (DR), which is characterized by …

Molecular targets of antihypertensive peptides: understanding the mechanisms of action based on the pathophysiology of hypertension

K Majumder, J Wu - International journal of molecular sciences, 2014 - mdpi.com
There is growing interest in using functional foods or nutraceuticals for the prevention and
treatment of hypertension or high blood pressure. Although numerous preventive and …

The renin–angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts

CM Ferrario, L Groban, H Wang, X Sun… - Kidney international …, 2022 - Elsevier
A large body of evidence implicates the renin–angiotensin system in the pathogenesis of
cardiovascular disease. However, not everyone understands that the magnitude of the risk …