Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

This review explores the multifaceted role that iron has in cancer biology. Epidemiological
studies have demonstrated an association between excess iron and increased cancer …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Mitochondrial Ca2+ ions are crucial regulators of bioenergetics and cell death pathways.
Mitochondrial Ca2+ content and cytosolic Ca2+ homeostasis strictly depend on Ca2+ …

Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria
encompass an active organellar network that fuses, divides, and directs a myriad of vital …

In the human body, trace elements and other micronutrients play a vital role in growth, health
and immune system function. The trace elements are Iron, Manganese, Copper, Iodine, Zinc …

Metal-based complexes have occupied a pioneering niche in the treatment of many chronic
diseases, including various types of cancers. Despite the phenomenal success of cisplatin …

Ca2+ transport across the inner membrane of mitochondria (IMM) is of major importance for
their functions in bioenergetics, cell death and signaling. It is therefore tightly regulated. It …

Multidrug resistance (MDR) in cancer is one of the major obstacles of chemotherapy. We
have recently identified a series of 8-hydroxyquinoline Mannich base derivatives with MDR …

Hydroxyquinolines (HQ), including clioquinol, possess cytotoxic properties and are widely
used as ligands for metal-based anticancer drug research. The number and identity of …