Cellular stress and RNA splicing
G Biamonti, JF Caceres - Trends in biochemical sciences, 2009 - cell.com
In response to physical and chemical stresses that affect protein folding and, thus, the
execution of normal metabolic processes, cells activate gene-expression strategies aimed at …
execution of normal metabolic processes, cells activate gene-expression strategies aimed at …
Challenges and opportunities in the purification of recombinant tagged proteins
The purification of recombinant proteins by affinity chromatography is one of the most
efficient strategies due to the high recovery yields and purity achieved. However, this is …
efficient strategies due to the high recovery yields and purity achieved. However, this is …
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing
Increasing evidence suggests that chromatin modifications have important roles in
modulating constitutive or alternative splicing. Here we demonstrate that the PWWP domain …
modulating constitutive or alternative splicing. Here we demonstrate that the PWWP domain …
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis
G Michlewski, JF Cáceres - Nature structural & molecular biology, 2010 - nature.com
The pluripotency-promoting proteins Lin28a and Lin28b act as post-transcriptional
repressors of let-7 miRNA biogenesis in undifferentiated embryonic stem cells. The levels of …
repressors of let-7 miRNA biogenesis in undifferentiated embryonic stem cells. The levels of …
Posttranscriptional regulation of miRNAs harboring conserved terminal loops
We recently found that hnRNP A1, a protein implicated in many aspects of RNA processing,
acts as an auxiliary factor for the Drosha-mediated processing of a microRNA precursor, pri …
acts as an auxiliary factor for the Drosha-mediated processing of a microRNA precursor, pri …
The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1
Summary The SR protein SF2/ASF has been initially characterized as a splicing factor but
has also been shown to mediate postsplicing activities such as mRNA export and …
has also been shown to mediate postsplicing activities such as mRNA export and …
Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases
B Sehnert, H Burkhardt, S Dübel, RE Voll - Cells, 2020 - mdpi.com
Deregulated NF-k activation is not only involved in cancer but also contributes to the
pathogenesis of chronic inflammatory diseases like rheumatoid arthritis (RA) and multiple …
pathogenesis of chronic inflammatory diseases like rheumatoid arthritis (RA) and multiple …
Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor
The Ser/Arg-rich (SR) proteins constitute a family of highly conserved nuclear
phosphoproteins that are involved in many steps of mRNA metabolism. Previously, we …
phosphoproteins that are involved in many steps of mRNA metabolism. Previously, we …
Genetic variation and RNA structure regulate microRNA biogenesis
N Fernandez, RA Cordiner, RS Young, N Hug… - Nature …, 2017 - nature.com
MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of
sequence and secondary RNA structure in this process has not been extensively studied. A …
sequence and secondary RNA structure in this process has not been extensively studied. A …
Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF
The serine and arginine-rich protein family (SR proteins) are highly conserved regulators of
pre-mRNA splicing. SF2/ASF, a prototype member of the SR protein family, is a …
pre-mRNA splicing. SF2/ASF, a prototype member of the SR protein family, is a …