Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …

The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes …

Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

Abstract Diurnal (ie., 24-hour) oscillations of the gut microbiome have been described in
various species including mice and humans. However, the driving force behind these …

Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Bile acids are endocrine molecules that in addition to facilitating the absorption of fat-soluble
nutrients regulate numerous metabolic processes, including glucose, lipid, and energy …