Opportunities and challenges for machine learning-assisted enzyme engineering
Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …
Biocatalytic reductive aminations with NAD (P) H-dependent enzymes: enzyme discovery, engineering and synthetic applications
Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …
reductive amination is one of the most efficient and atom economic methodologies for the …
Imine Reductases and Reductive Aminases in Organic Synthesis
GA Aleku - ACS Catalysis, 2024 - ACS Publications
Imine reductases (IREDs) and reductive aminases (RedAms) are NADPH-dependent
oxidoreductases catalyzing C–N redox reactions. These include the enantioselective …
oxidoreductases catalyzing C–N redox reactions. These include the enantioselective …
Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities
Molecular docking is a computational method based on bioinformatics that simulates the
interaction dynamics of molecules such as ligands and receptors, predicting their binding …
interaction dynamics of molecules such as ligands and receptors, predicting their binding …
[HTML][HTML] Kinetic and structural analysis of redox-reversible artificial imine reductases
AH Miller, IBS Martins, EV Blagova, KS Wilson… - Journal of Inorganic …, 2024 - Elsevier
Three artificial imine reductases, constructed via supramolecular anchoring utilising Fe III-
azotochelin, a natural siderophore, to bind an iridium-containing catalyst to periplasmic …
azotochelin, a natural siderophore, to bind an iridium-containing catalyst to periplasmic …
Data-Driven Construction of an Imine Reductase Library Capable of Broad-Scope Reductive Amination at Equimolar Substrate Concentrations
SA Berger, C Grimm, M Cespugli, A Krassnigg… - 2024 - chemrxiv.org
Reductive amination catalysed by imine reductase (IRED) and reductive aminase (RedAm)
enzymes has recently been established as a powerful method for the asymmetric synthesis …
enzymes has recently been established as a powerful method for the asymmetric synthesis …
SignatureFinder enables sequence mining to identify cobalamin‐dependent photoreceptor proteins
Photoreceptors control cellular processes in response to light. Most photoreceptors sense
blue or red light, but the recent discovery of the cobalamin‐dependent photoreceptor, CarH …
blue or red light, but the recent discovery of the cobalamin‐dependent photoreceptor, CarH …