Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of
water, and in some cases, small solutes across the membrane. They are conserved in …

A number of ion channels and transporters are expressed in both the inner ear and kidney.
In the inner ear, K+ cycling and endolymphatic K+, Na+, Ca2+, and pH homeostasis are …

A role for aquaporins (AQPs) in hearing has been suggested from the specific expression of
aquaporins in inner ear and the need for precise volume regulation in epithelial cells …

The long-standing biophysical question of how water crosses plasma membranes has been
answered by the recent discovery of the aquaporins. Identification of this large family of …

Mammalian aquaporins constitute a family of so far 10 related water channel proteins which
mediate osmotically driven water fluxes across the plasma membrane. Because regulation …

Aquaporins (AQPs) confer a high water permeability on cell membranes and play important
parts in secretory and absorptive epithelia in kidney and other organs. Here we investigate …

Hearing impairment is the most frequent sensory deficit in humans. Deafness genes, which
harbor pathogenic mutations that have been identified in families with hereditary hearing …

The expression pattern of aquaporin-2 (AQP2), a vasopressin regulated member of the
aquaporin gene family, in the cochlea and its potential role in Meniere's disease was …

The inner ear is a fluid-filled sensory organ that transforms mechanical stimuli into the
senses of hearing and balance. These neurosensory functions depend on the strict …

Gene transfer has been performed in a variety of organs. In the mammalian inner ear, viral
vectors have been used to introduce exogenous reporter genes via the scala tympani into …