[HTML][HTML] Bat-borne virus diversity, spillover and emergence
Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
Latency and lytic replication in Epstein–Barr virus-associated oncogenesis
C Münz - Nature Reviews Microbiology, 2019 - nature.com
Epstein–Barr virus (EBV) was the first tumour virus identified in humans. The virus is
primarily associated with lymphomas and epithelial cell cancers. These tumours express …
primarily associated with lymphomas and epithelial cell cancers. These tumours express …
[HTML][HTML] CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases
G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …
research era. Genome modification studies have traveled a long way from gene …
Epstein–Barr virus and cancer
PJ Farrell - Annual Review of Pathology: Mechanisms of …, 2019 - annualreviews.org
Epstein–Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide,
and viral genes are expressed in the malignant cells. EBV also very efficiently causes the …
and viral genes are expressed in the malignant cells. EBV also very efficiently causes the …
CRISPR screens decode cancer cell pathways that trigger γδ T cell detection
Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …
broadly, independent of patient-specific neoantigens or human leukocyte antigen …
[HTML][HTML] SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
Abstract The recently identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) is the cause of the COVID-19 pandemic. How this novel beta-coronavirus virus, and …
CoV-2) is the cause of the COVID-19 pandemic. How this novel beta-coronavirus virus, and …
Am I ready for CRISPR? A user's guide to genetic screens
JG Doench - Nature Reviews Genetics, 2018 - nature.com
Exciting new technologies are often self-limiting in their rollout, as access to state-of-the-art
instrumentation or the need for years of hands-on experience, for better or worse, ensures …
instrumentation or the need for years of hands-on experience, for better or worse, ensures …
[HTML][HTML] Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
Host dependency factors that are required for influenza A virus infection may serve as
therapeutic targets as the virus is less likely to bypass them under drug-mediated selection …
therapeutic targets as the virus is less likely to bypass them under drug-mediated selection …
[HTML][HTML] Epstein-barr-virus-induced one-carbon metabolism drives B cell transformation
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas.
How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely …
How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely …
[HTML][HTML] A structure-informed atlas of human-virus interactions
G Lasso, SV Mayer, ER Winkelmann, T Chu, O Elliot… - Cell, 2019 - cell.com
While knowledge of protein-protein interactions (PPIs) is critical for understanding virus-host
relationships, limitations on the scalability of high-throughput methods have hampered their …
relationships, limitations on the scalability of high-throughput methods have hampered their …