[HTML][HTML] Bat-borne virus diversity, spillover and emergence

M Letko, SN Seifert, KJ Olival, RK Plowright… - Nature Reviews …, 2020 - nature.com
Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …

Latency and lytic replication in Epstein–Barr virus-associated oncogenesis

C Münz - Nature Reviews Microbiology, 2019 - nature.com
Epstein–Barr virus (EBV) was the first tumour virus identified in humans. The virus is
primarily associated with lymphomas and epithelial cell cancers. These tumours express …

[HTML][HTML] CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases

G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

Epstein–Barr virus and cancer

PJ Farrell - Annual Review of Pathology: Mechanisms of …, 2019 - annualreviews.org
Epstein–Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide,
and viral genes are expressed in the malignant cells. EBV also very efficiently causes the …

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

MR Mamedov, S Vedova, JW Freimer, AD Sahu… - Nature, 2023 - nature.com
Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …

[HTML][HTML] SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Y Zhang, R Guo, SH Kim, H Shah, S Zhang… - Nature …, 2021 - nature.com
Abstract The recently identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) is the cause of the COVID-19 pandemic. How this novel beta-coronavirus virus, and …

Am I ready for CRISPR? A user's guide to genetic screens

JG Doench - Nature Reviews Genetics, 2018 - nature.com
Exciting new technologies are often self-limiting in their rollout, as access to state-of-the-art
instrumentation or the need for years of hands-on experience, for better or worse, ensures …

[HTML][HTML] Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

B Li, SM Clohisey, BS Chia, B Wang, A Cui… - Nature …, 2020 - nature.com
Host dependency factors that are required for influenza A virus infection may serve as
therapeutic targets as the virus is less likely to bypass them under drug-mediated selection …

[HTML][HTML] Epstein-barr-virus-induced one-carbon metabolism drives B cell transformation

LW Wang, H Shen, L Nobre, I Ersing, JA Paulo… - Cell metabolism, 2019 - cell.com
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas.
How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely …

[HTML][HTML] A structure-informed atlas of human-virus interactions

G Lasso, SV Mayer, ER Winkelmann, T Chu, O Elliot… - Cell, 2019 - cell.com
While knowledge of protein-protein interactions (PPIs) is critical for understanding virus-host
relationships, limitations on the scalability of high-throughput methods have hampered their …