Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been
recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of …

Bacteria have evolved a variety of signal transduction mechanisms that generate different
outputs in response to external stimuli. Chemosensory pathways are widespread in bacteria …

Most microbes in the biosphere are attached to surfaces, where they experience mechanical
forces due to hydrodynamic flow and cell-to-substratum interactions. These forces likely …

To initiate biofilm formation, it is critical for bacteria to sense a surface and respond precisely
to activate downstream components of the biofilm program. Type 4 pili (T4P) and increasing …

Attachment of bacteria onto a surface, consequent signaling, and accumulation and growth
of the surface-bound bacterial population are key initial steps in the formation of pathogenic …

Biofilm formation by Pseudomonas aeruginosa is primarily responsible for chronic wound
and lung infections in humans. These infections are persistent owing to the biofilm's high …

Bacteria thrive in environments rich in fluid flow, such as the gastrointestinal tract,
bloodstream, aquatic systems, and the urinary tract. Despite the importance of flow, how flow …

Plastics released in the environment become suitable matrices for microbial attachment and
colonization. Plastics-associated microbial communities interact with each other and are …

Bacterial biofilms are among the most abundant multicellular structures on Earth and play
essential roles in a wide range of ecological, medical, and industrial processes. However …

Chronic biofilm infections by Pseudomonas aeruginosa are a major contributor to the
morbidity and mortality of patients. The formation of multicellular bacterial aggregates, called …