Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

Maternal immune activation (MIA) during pregnancy has been linked to an increased risk of
developing psychiatric pathologies in later life. This link may be bridged by a defective …

Neuroinflammation is implicated in the pathogenesis of a wide range of neurologic and
neuropsychiatric diseases. For over 20 years, 11C-PK11195 PET, which aims to image …

Abstract Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that
catalyzes the selective removal of phosphate groups from protein serine and threonine …

Alzheimer's disease (AD) is the most common cause of dementia. Neuroinflammation
appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator …

Objective Surgery launches a systemic inflammatory reaction that reaches the brain and
associates with immune activation and cognitive decline. Although preclinical studies have …

Purpose Over the past 20 years, neuroinflammation (NI) has increasingly been recognised
as having an important role in many neurodegenerative diseases, including Alzheimer's …

Abstract Fingolimod phosphate (FTY720), the first approved oral therapy for multiple
sclerosis, primarily acts as an immunomodulator. Its concomitant effects in the central …

Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain,
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …