The myriad of peptides presented at the cell surface by class I and class II major
histocompatibility complex (MHC) molecules are referred to as the immunopeptidome and …

Peptide antigens bound to molecules encoded by the major histocompatibility complex
(MHC) and presented on the cell surface form the targets of T lymphocytes. This critical arm …

The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …

The magnitude of T cell responses to infection is a function of the naïve T cell repertoire
combined with the context and duration of antigen presentation. Using mass spectrometry …

An effective human immunodeficiency virus type 1 (HIV-1) vaccine is the best solution for
halting the acquired immune deficiency syndrome epidemic. Here, we describe the design …

Many immunotherapeutic approaches under development rely on T-cell recognition of
cancer-derived peptides bound to human leukocyte antigen molecules on the cell surface …

Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense
mechanism against intracellular pathogens. High‐throughput definition of HLA class I …

Elucidation of novel peptides presented by human leukocyte antigen (HLA) class I alleles by
immunopeptidomics constitutes a powerful approach that can inform the rational design of …

Non-classical class Ib MHC-E molecule is becoming an increasingly interesting component
of the immune response. It is involved in both the adaptive and innate immune responses to …

The potency of viral vector-based vaccines depends on their ability to induce strong
transgene-specific immune response without triggering anti-vector immunity. Previously, Orf …