mTOR complex 2 signaling and functions
WJ Oh, E Jacinto - Cell cycle, 2011 - Taylor & Francis
The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
The anaplastic lymphoma kinase in the pathogenesis of cancer
Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
M Marzec, Q Zhang, A Goradia… - Proceedings of the …, 2008 - National Acad Sciences
The mechanisms of malignant cell transformation caused by the oncogenic, chimeric
nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) remain only partially understood …
nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) remain only partially understood …
Anaplastic lymphoma kinase: signalling in development and disease
RH Palmer, E Vernersson, C Grabbe… - Biochemical …, 2009 - portlandpress.com
RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …
Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms
M Jiang, NN Bennani, AL Feldman - Expert review of hematology, 2017 - Taylor & Francis
Introduction: Lymphomas are classified based on the normal counterpart, or cell of origin,
from which they arise. Because lymphocytes have physiologic immune functions that vary …
from which they arise. Because lymphocytes have physiologic immune functions that vary …
Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors
CM Lovly, JM Heuckmann, E de Stanchina, H Chen… - Cancer research, 2011 - AACR
Aberrant forms of the anaplastic lymphoma kinase (ALK) have been implicated in the
pathogenesis of multiple human cancers, where ALK represents a rational therapeutic target …
pathogenesis of multiple human cancers, where ALK represents a rational therapeutic target …
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy
TR Webb, J Slavish, RE George, AT Look… - Expert review of …, 2009 - Taylor & Francis
Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor
superfamily, was initially identified in constitutively activated oncogenic fusion forms–the …
superfamily, was initially identified in constitutively activated oncogenic fusion forms–the …
B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders
RA Wilcox, AL Feldman, DA Wada… - Blood, The Journal …, 2009 - ashpublications.org
Stromal elements present within the tumor microenvironment may suppress host immunity
and promote the growth of malignant lymphocytes in B cell–derived non-Hodgkin lymphoma …
and promote the growth of malignant lymphocytes in B cell–derived non-Hodgkin lymphoma …
Myc proteins as therapeutic targets
WC Gustafson, WA Weiss - Oncogene, 2010 - nature.com
Myc proteins (c-myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for
progression in cancer. Amplification of the MYCN gene has emerged as one of the clearest …
progression in cancer. Amplification of the MYCN gene has emerged as one of the clearest …
Pathobiology of ALK+ anaplastic large-cell lymphoma
HM Amin, R Lai - Blood, The Journal of the American Society of …, 2007 - ashpublications.org
Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic
features and the consistent expression of CD30. It then became evident that the majority of …
features and the consistent expression of CD30. It then became evident that the majority of …