Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use
patient-specific somatic cells, which are a valuable source for disease modeling and drug …

Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene
products, reverse the modification of proteins by a single ubiquitin (-like) protein, and …

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype that
accounts for nearly 10% of gastric carcinomas. EBVaGC is defined by monoclonal …

Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate
relationship with their host, and as such, their genomes have been shaped directly by …

Nasopharyngeal carcinoma (NPC), also named the Cantonese cancer, is a unique cancer
with strong etiological association with infection of the Epstein-Barr virus (EBV). With …

Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary
drivers of tumor formation and cancer progression. These alterations can endow cells with a …

Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS).
Components of this pathway, including the proteasome, ubiquitinating enzymes and …

The ubiquitin-specific protease, USP7, has key roles in the p53 pathway whereby it
stabilizes both p53 and MDM2. We show that the N-terminal domain of USP7 binds two …