Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

The cadherin-catenin adhesion complex is the key component of the intercellular adherens
junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial …

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How
talin and vinculin respond to forces and regulate one another remains unclear. By …

Force sensing at cadherin-mediated adhesions is critical for their proper function. α-Catenin,
which links cadherins to actomyosin, has a crucial role in this mechanosensing process. It …

The force-dependent interaction between talin and vinculin plays a crucial role in the
initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the …

Background Cells sense the extracellular environment using adhesion receptors (integrins)
linked to the intracellular actin cytoskeleton through a complex network of regulatory …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a
linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report …

Cells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to
the ECM is a key step in their migration through tissues. Integrins are important receptors for …

Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for
both cell–cell and cell–extracellular matrix (focal adhesion) adherens-type junctions, but its …