Vinculin in cell–cell and cell–matrix adhesions

JL Bays, KA DeMali - Cellular and Molecular Life Sciences, 2017 - Springer
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

Integration of cadherin adhesion and cytoskeleton at adherens junctions

RM Mège, N Ishiyama - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
The cadherin-catenin adhesion complex is the key component of the intercellular adherens
junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial …

Allosteric activation of vinculin by talin

F Franz, R Tapia-Rojo, S Winograd-Katz… - Nature …, 2023 - nature.com
The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How
talin and vinculin respond to forces and regulate one another remains unclear. By …

Force-dependent conformational switch of α-catenin controls vinculin binding

M Yao, W Qiu, R Liu, AK Efremov, P Cong… - Nature …, 2014 - nature.com
Force sensing at cadherin-mediated adhesions is critical for their proper function. α-Catenin,
which links cadherins to actomyosin, has a crucial role in this mechanosensing process. It …

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

M Yao, BT Goult, H Chen, P Cong, MP Sheetz, J Yan - Scientific reports, 2014 - nature.com
The force-dependent interaction between talin and vinculin plays a crucial role in the
initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the …

Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner

A Carisey, R Tsang, AM Greiner, N Nijenhuis, N Heath… - Current biology, 2013 - cell.com
Background Cells sense the extracellular environment using adhesion receptors (integrins)
linked to the intracellular actin cytoskeleton through a complex network of regulatory …

Regulation of actin assembly associated with protrusion and adhesion in cell migration

C Le Clainche, MF Carlier - Physiological reviews, 2008 - journals.physiology.org
To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

A Kumar, M Ouyang, K Van den Dries… - Journal of Cell …, 2016 - rupress.org
Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a
linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report …

Turnover of focal adhesions and cancer cell migration

M Nagano, D Hoshino, N Koshikawa… - … journal of cell …, 2012 - Wiley Online Library
Cells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to
the ECM is a key step in their migration through tissues. Integrins are important receptors for …

The structure and regulation of vinculin

WH Ziegler, RC Liddington, DR Critchley - Trends in cell biology, 2006 - cell.com
Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for
both cell–cell and cell–extracellular matrix (focal adhesion) adherens-type junctions, but its …