Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …

High mortality rates due to cardiovascular diseases (CVDs) have attracted worldwide
attention. It has been reported that mitochondrial dysfunction is one of the most important …

Mitochondria calcium is a double-edged sword. While low levels of calcium are essential to
maintain optimal rates of ATP production, extreme levels of calcium overcoming the …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere
protein-encoding genes (ie genotype-positive HCM). In an increasing number of patients …

Background: Defects in energetics are thought to be central to the pathophysiology of
hypertrophic cardiomyopathy (HCM); yet, the determinants of ATP availability are not known …

Dilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as
thinning and enlargement of left ventricular chambers. These characteristics eventually lead …

Semaglutide, a glucagon-like peptide-1 receptor agonist, is clinically used as a glucose-
lowering and weight loss medication due to its effects on energy metabolism. In heart failure …