The lack of effective treatments for pulmonary diseases presents a significant global health
burden, primarily due to the challenges posed by the pulmonary barrier that hinders drug …

In the last decade, biological drugs have rapidly proliferated and have now become an
important therapeutic modality. This is because of their high potency, high specificity and …

Drug delivery to the lungs by inhalation offers a targeted drug therapy for respiratory
diseases. However, the therapeutic efficacy of inhaled drugs is limited by their rapid …

Remarkably, with the exception of anaesthetic gases, the ancient human practice of inhaling
substances into the lungs for systemic effect has only just begun to be adopted by modern …

We are providing an update to our previously published review paper on inhaled
nanoparticles, thus updating with the most recent reports in the literature. The field of …

The field of nanotechnology may hold the promise of significant improvements in the health
and well being of patients, as well as in manufacturing technologies. The knowledge of this …

Despite the interest in systemic delivery of therapeutic molecules including macromolecular
proteins and peptides via the lung, the accurate assessment of their pulmonary …

This work presents a new dry powder system consisting of microencapsulated protein-
loaded chitosan nanoparticles (CS NPs). The developed system was evaluated in vivo in …

Although there is a modest body of literature on the absorption of inhaled pharmaceuticals
by normal lungs and some limited information from diseased lungs, there is still a surprising …

Delivering therapeutic agents to the lungs requires a deep understanding of the kinetics and
dynamics of drugs in this biologically and physiologically complex system. In this chapter …