Some recent approaches of biologically active substituted pyridazine and phthalazine drugs
M Asif - Current medicinal chemistry, 2012 - ingentaconnect.com
Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and
phthalazines are important structural feature of many biologically active compounds and …
phthalazines are important structural feature of many biologically active compounds and …
The effect of pyridazine compounds on the cardiovascular system
M Asif, A Singh, AA Siddiqui - Medicinal Chemistry Research, 2012 - Springer
Many natural as well as synthetic heterocylic compounds are known to have different
biological activities. The pyridazine moiety is an important structural feature of many …
biological activities. The pyridazine moiety is an important structural feature of many …
Design, synthesis, and aldose reductase inhibitory effect of some novel carboxylic acid derivatives bearing 2-substituted-6-aryloxo-pyridazinone moiety
The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol
and then converted to fructose. The first and rate limiting enzyme of this pathway, aldose …
and then converted to fructose. The first and rate limiting enzyme of this pathway, aldose …
Comparative study of DFT/B3LYP, B3PW91, and HSEH1PBE methods applied to molecular structures and spectroscopic and electronic properties of flufenpyr and …
The optimized molecular structures, conformational analyses, vibrational (IR) frequencies
and their assignments, maximum electronic absorption wavelengths (gas phase and in …
and their assignments, maximum electronic absorption wavelengths (gas phase and in …
3 (2H)-pyridazinone derivatives: Synthesis, in-silico studies, structure-activity relationship and in-vitro evaluation for acetylcholinesterase enzyme inhibition
ÖF Çöl, İ Bozbey, B Türkmenoğlu, M Uysal - Journal of Molecular Structure, 2022 - Elsevier
New ten compounds bearing pyridazinone ring (5a–j) were designed and synthesized as
acetylcholinesterase inhibitors. The new derivatives were acquired via the reaction of …
acetylcholinesterase inhibitors. The new derivatives were acquired via the reaction of …
Recent achievements in the chemistry of 1, 2-diazines
II Mangalagiu - Current Organic Chemistry, 2011 - ingentaconnect.com
Recent studies have centred on 1, 2-diazines derivatives, which proved to be invaluable
materials in the fields of medicine, opto-electronics and agriculture. 1, 2-diazines were found …
materials in the fields of medicine, opto-electronics and agriculture. 1, 2-diazines were found …
Synthesis of some new 2,6-disubstituted-3(2H)-pyridazinone derivatives and investigation of their analgesic, anti-inflammatory and antimicrobial activities
D Tiryaki, M Sukuroglu, DS Dogruer, E Akkol… - Medicinal Chemistry …, 2013 - Springer
Abstract In this study, 12 new 3 (2 H)-pyridazinone derivatives carrying 4-substituted
phenylpiperazinylethyl moiety on lactam nitrogen were synthesized and their chemical …
phenylpiperazinylethyl moiety on lactam nitrogen were synthesized and their chemical …
A mini-review on pyridazine analogs: Chemical and pharmacological potentials
S Alghamdi, M Asif - Mini-Reviews in Organic Chemistry, 2023 - ingentaconnect.com
The pyridazinone derivatives have diverse biological potential and are easily synthesized.
Due to this, researchers and chemists have paid attention to the design and development of …
Due to this, researchers and chemists have paid attention to the design and development of …
Pyridazinones and pyrrolones as promising Scaffolds in Medicinal Chemistry
MS Abdelbaset, M Abdel-Aziz… - Journal of advanced …, 2019 - journals.ekb.eg
Pyridazinones and pyrrolones are important building blocks for some important drugs such
as the naturally occurring antibacterial pyrrolone, althiomycin; the cardiotonic pyridazinones …
as the naturally occurring antibacterial pyrrolone, althiomycin; the cardiotonic pyridazinones …
Synthesis of some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives incorporating aminothiazole moiety and investigation of their antioxidant …
C Yamalı, H Ozan Gülcan, B Kahya… - Medicinal Chemistry …, 2015 - Springer
In this study, 12 new compounds were synthesized, six of which were 3 (2 H)-pyridazinone
(9a–f) and the others were 1 (2 H)-phthalazinone (10a–f) derivatives. The chemical …
(9a–f) and the others were 1 (2 H)-phthalazinone (10a–f) derivatives. The chemical …