The peripheral immune system plays a critical role in aging and in the response to brain
injury. Emerging data suggest inflammatory responses are exacerbated in older animals …

Cell therapy has the potential to improve healing of ischemic heart, repopulate injured
myocardium and restore cardiac function. The tremendous hope and potential of stem cell …

Cell therapy has received significant attention as a therapeutic approach to restore cardiac
function after myocardial infarction. Accumulating evidence supports that beneficial effects …

Ischemic cardiac injury is the main contributor to heart failure, and the regenerative capacity
of intrinsic stem cells plays an important role in tissue repair after injury. However, stem cells …

Background Aging is one of the key factors that regulate the function of human bone marrow
mesenchymal stem cells (hBM-MSCs) and related changes in microRNA (miRNA) …

Cellular therapy to treat heart failure is an ongoing focus of intense research, but progress
toward structural and functional recovery remains modest. Engineered augmentation of …

Recruited immune cells play a critical role in muscle repair, in part by interacting with local
stem cell populations to regulate muscle regeneration. How aging affects their …

Cell therapy has received significant attention as a novel therapeutic approach to restore
cardiac function after injury. CD34-positive (CD34+) stem cells have been investigated for …

In the past two decades, thousands of non-coding RNAs (ncRNAs) have been discovered,
annotated, and characterized in nearly every tissue under both physiological and …

Reduced quantity and quality of stem cells in aged individuals hinders cardiac repair and
regeneration after injury. We used young bone marrow (BM) stem cell antigen 1 (Sca‐1) …