Inhibitors of apoptosis: clinical implications in cancer
Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …
main regulators of caspase activity and cell death. They are considered the main culprits in …
Structural insights into the activation mechanisms of human HtrA serine proteases
D Zurawa-Janicka, T Wenta, M Jarzab… - Archives of biochemistry …, 2017 - Elsevier
Human HtrA1-4 proteins belong to the HtrA family of evolutionarily conserved serine
proteases and function as important modulators of many physiological processes, including …
proteases and function as important modulators of many physiological processes, including …
Rationally modulate the oxidase-like activity of nanoceria for self-regulated bioassays
One of the current challenges in nanozyme-based technology is to rationally control the
enzyme mimicking activities with suitable modulation strategies to mimic the complexity and …
enzyme mimicking activities with suitable modulation strategies to mimic the complexity and …
Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR
Human High temperature requirement A2 (HtrA2) is a mitochondrial protease chaperone
that plays an important role in cellular proteostasis and in regulating cell-signaling events …
that plays an important role in cellular proteostasis and in regulating cell-signaling events …
Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease
Y Toyama, RW Harkness… - Proceedings of the …, 2022 - National Acad Sciences
The human high-temperature requirement A2 (HtrA2) protein is a trimeric protease that
cleaves misfolded proteins to protect cells from stresses caused by toxic, proteinaceous …
cleaves misfolded proteins to protect cells from stresses caused by toxic, proteinaceous …
Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease
EE Aspholm, J Lidman, BM Burmann - Nature Communications, 2024 - nature.com
The mitochondrial serine protease HtrA2 is a human homolog of the Escherichia coli Deg-
proteins exhibiting chaperone and proteolytic roles. HtrA2 is involved in both apoptotic …
proteins exhibiting chaperone and proteolytic roles. HtrA2 is involved in both apoptotic …
Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region
Y Li, Y Wei, M Ultsch, W Li, W Tang, B Tombling… - Nature …, 2024 - nature.com
Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional
chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a …
chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a …
Unraveling the dichotomy of enigmatic serine protease HtrA2
Mitochondrial high-temperature requirement protease A2 (HtrA2) is an integral member of
the HtrA family of serine proteases that are evolutionarily conserved from prokaryotes to …
the HtrA family of serine proteases that are evolutionarily conserved from prokaryotes to …
A general strategy to inhibit serine protease by targeting its autolysis loop
Serine proteases are a large family of enzymes critical for multiple physiological processes,
and proven diagnostic and therapeutic targets in several clinical indications. The high …
and proven diagnostic and therapeutic targets in several clinical indications. The high …
Protein purification by affinity chromatography
S Dutta, K Bose - Textbook on Cloning, Expression and Purification of …, 2022 - Springer
Affinity chromatography involves targeted purification of biological macromolecules from a
crude mixture on the basis of highly specific interaction between the macromolecule and a …
crude mixture on the basis of highly specific interaction between the macromolecule and a …