Summary July 20, 2021 marked the 30th anniversary of the publication of the landmark trial
by the British Medical Research Council showing unequivocally that maternal intake of folic …

For three decades, the US Public Health Service has recommended that all persons capable
of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects …

Importance Uncertainty remains about the efficacy of folic acid therapy for the primary
prevention of stroke because of limited and inconsistent data. Objective To test the primary …

Cancer‐related anemia (CRA) is due to multiple etiologies, including chemotherapy‐
induced myelosuppression, blood loss, functional iron deficiency, erythropoietin deficiency …

Anemia is a multifactorial condition; approaches to address it must recognize that the causal
factors represent an ecology consisting of internal (biology, genetics, and health) and …

The neural tube defects anencephaly and spina bifida are two of the most common serious
congenital malformations. Most cases can be prevented by consuming sufficient folic acid …

Background Folate is a B‐vitamin required for DNA synthesis, methylation, and cellular
division. Wheat and maize (corn) flour are staple crops consumed widely throughout the …

BACKGROUND The prevalence of neural tube defects (NTDs) in northern China is among
the highest in the world. A massive folic acid supplementation program as a specific …

Background Spina bifida and anencephaly are two major neural tube defects. They
contribute substantially to perinatal, neonatal, infant, and under‐five mortality and life‐long …

Erythropoiesis, the bone marrow production of erythrocytes by the proliferation and
differentiation of hematopoietic cells, replaces the daily loss of 1% of circulating erythrocytes …