Glutamate is the major excitatory neurotransmitter in the mammalian CNS. The
spatiotemporal profile of the glutamate concentration in the synapse is critical for excitatory …

After 50 years, the heterologous expression of proteins in Xenopus laevis oocytes is still
essential in many research fields. New approaches and revised protocols, but also classical …

The norepinephrine transporter (NET) mediates reuptake of norepinephrine released from
neurons, and, as such, it is an important regulator of noradrenergic neurotransmission …

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous
system (CNS). Its homeostasis is maintained by neuronal and glial GABA transporters …

ABSTRACT The Nramp (Slc11) protein family is widespread in bacteria and eukaryotes, and
mediates transport of divalent metals across cellular membranes. The social amoeba …

The high‐affinity/low‐capacity system Slc15a2 (PepT2) is responsible for the reuptake of
di/tripeptides from the renal proximal tubule, but it also operates in many other tissues and …

Hyperekplexia or startle disease is characterized by an exaggerated startle response,
evoked by tactile or auditory stimuli, producing hypertonia and apnea episodes. Although …

The rat γ‐aminobutyric acid transporter‐1 (GAT‐1) was expressed in Xenopus laevis
oocytes and the substrate‐independent Li+‐induced leak current was examined using two …

Betaine is an endogenous osmolyte that exhibits therapeutic potential by mitigating various
neurological disorders. However, the underlying cellular and molecular mechanisms …

The entire substrate translocation pathway in the human GABA transporter (GAT-1) was
explored for the endogenous substrate GABA and the anti-convulsive drug tiagabine …