[HTML][HTML] Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways

UEA Ruiz, IA Santos, VR Grosche, RS Fernandes… - Virus Research, 2023 - Elsevier
The Chikungunya virus (CHIKV) causes Chikungunya fever, a disease characterized by
symptoms such as arthralgia/polyarthralgia. Currently, there are no antivirals approved …

MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo

S De, S Ghosh, SS Keshry, C Mahish… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
The increase in disease incidences and persistent Chikungunya virus (CHIKV)-induced
arthritis have been a huge burden on public health globally. In the absence of specific …

4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

P Yin, NA May, LS Lello, A Fayed, MG Parks… - Mbio, 2024 - Am Soc Microbiol
Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged
to cause millions of human infections worldwide. In humans, acute CHIKV infection causes …

Ex vivo gut cultures of Aedes aegypti are efficiently infected by mosquito-borne alpha- and flaviviruses

AL Rosales Rosas, L Wang, S Goossens… - Microbiology …, 2023 - Am Soc Microbiol
Aedes aegypti mosquitoes can transmit several arboviruses, including chikungunya virus
(CHIKV), dengue virus (DENV), and Zika virus (ZIKV). When blood-feeding on a virus …

Efeitos da imidazonaftiridina na infecção pelo vírus chikungunya: atividade antiviral por uma via independente do interferon tipo 1?

UEA Ruiz - 2022 - repositorio.ufu.br
RESUMO O vírus Chikungunya (CHIKV), agente causador da febre Chikungunya, é
transmitido principalmente pela picada de mosquitos hematófagos do gênero Aedes. A …