Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival
inflammation and bone loss. Periodontitis is associated with various systemic diseases …

Macrophage polarization in chronic inflammatory diseases: killers or builders?

L Parisi, E Gini, D Baci, M Tremolati… - Journal of …, 2018 - Wiley Online Library
Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

[HTML][HTML] Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

L Jia, N Han, J Du, L Guo, Z Luo, Y Liu - Frontiers in cellular and …, 2019 - frontiersin.org
Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases.
Recently, the regulation between host immunologic response and periodontal pathogens …

[HTML][HTML] Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis …

AB Gallimidi, S Fischman, B Revach, R Bulvik… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Oral squamous cell carcinoma (OSCC) is a lethal disease whose incidence is increasing.
Epidemiologic studies demonstrate an association between periodontitis and oral cancer …

Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later

G Hajishengallis, JM Korostoff - Periodontology 2000, 2017 - Wiley Online Library
In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …

The periodontal war: microbes and immunity

JL Ebersole, D Dawson III, P Emecen‐Huja… - Periodontology …, 2017 - Wiley Online Library
Maintenance of periodontal health or transition to a periodontal lesion reflects the
continuous and ongoing battle between the vast microbial ecology in the oral cavity and the …

[HTML][HTML] Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection

T Yoshimoto, M Kittaka, AAP Doan, R Urata… - Nature …, 2022 - nature.com
The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here,
we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated …

[HTML][HTML] Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases

LH Aleksijević, M Aleksijević, I Škrlec, M Šram, M Šram… - Pathogens, 2022 - mdpi.com
Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral
cavity. It is an integral part of the oral microbiome, which includes more than 500 types of …

Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone

R Gruber - Journal of Clinical Periodontology, 2019 - Wiley Online Library
Aim Osteoimmunology covers the cellular and molecular mechanisms responsible for
inflammatory osteolysis that culminates in the degradation of alveolar bone …

Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2-and IL-1–driven Th17 response

SG de Aquino, S Abdollahi-Roodsaz… - The Journal of …, 2014 - journals.aai.org
Increasing epidemiologic evidence supports a link between periodontitis and rheumatoid
arthritis. The actual involvement of periodontitis in the pathogenesis of rheumatoid arthritis …