Globally, liver cancer is the most frequent fatal malignancy; in the United States, it ranks fifth.
Patients are often diagnosed with liver cancer in advanced stages, contributing to its poor …

The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-
ERK signal cascade, functions to transmit upstream signals to its downstream effectors to …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality.
The principal treatment is surgical resection or liver transplantation, depending on whether …

Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous
molecular pathways are known to drive angiogenic switch in cancer cells promoting the …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

The identification of driver oncogenes has provided important targets for drugs that can
change the landscape of cancer therapies. One such example is the BRAF oncogene, which …

BACKGROUND & AIMS: The Sorafenib Hepatocellular Carcinoma (HCC) Assessment
Randomized Protocol (SHARP) trial demonstrated that sorafenib improves overall survival …

Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate …

Resistance to conventional and target specific antitumor drugs still remains one of the major
cause of treatment failure and patience death. This condition often involves ATP-binding …