Valvular heart disease is an important source of cardiovascular morbidity and mortality.
Current prosthetic valve replacement options, such as bioprosthetic and mechanical heart …

Enzymes catalyze biochemical reactions and play critical roles in human health and
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …

Heart valve replacement has become an optimal choice for the treatment of severe heart
valve disease. At present, most commercial bioprosthetic heart valves (BHVs) are made from …

Valve replacement is the main therapy for valvular heart disease, in which a diseased valve
is replaced by mechanical heart valve (MHV) or bioprosthetic heart valve (BHV). Since the …

Congenital heart diseases (CHDs) frequently impact the right ventricular outflow tract,
resulting in a significant incidence of pulmonary valve replacement in the pediatric …

While glycans are among the most abundant macromolecules on the cell with widespread
functions, their role in immunity has historically been challenging to study. This is in part due …

Valvular heart disease (VHD) has become a burden and a growing public health problem in
humans, causing significant morbidity and mortality worldwide. An increasing number of …

With the intensification of the aging population and the development of transcatheter heart
valve replacement technology (THVR), clinical demand for bioprosthetic valves is increasing …

OBJECTIVES Limited data are available from randomized trials comparing outcomes
between transcatheter aortic valve replacement (TAVR) and surgery in patients with different …

Aims Bioprosthetic aortic valve degeneration demonstrates pathological similarities to aortic
stenosis. Lipoprotein (a)[Lp (a)] is a well-recognized risk factor for incident aortic stenosis …