Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

The etiology of nerve cell death in neuronal degenerative diseases is unknown, but it has
been hypothesized that excitotoxic mechanisms may play a role. Such mechanisms may …

Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess
neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and …

Since the finding by Johnson and Ascher (1987) demonstrating that glycine enhances
electrophysiological responses mediated by N-methyl-D-aspartate (NMDA) b

A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs)
may play a key role in the pathophysiology of several neurological diseases, including …

It has long been assumed that l-forms of amino acids exclusively constitute free amino acid
pools in mammals. However, a variety of studies in the last decade has demonstrated that …

This paper reviews chemical models of epilepsy and their relevance in the identification and
characterization of anticonvulsants. For each convulsant we discuss possible modes of …

A series of novel tricyclic pyrido-phthalazine-dione derivatives was tested for antagonistic
effects at the strychnine-insensitive modulatory site of the N-methyl-d-aspartate (NMDA) …

Fig. 1, Glutamate receptor pharmacology (recognition sites). A. Scheme showing the
recognition sites of the AMPA receptor. Agonists such as glutamate bind to two recognition …

This review examines progress in understanding the physiologic functions of glutamic acid
in the body since the first symposium on glutamic acid physiology and biochemistry was …