Background: It is generally assumed that radiation-induced chromosome breaks are the
result of a cell's inability to rejoin DNA double-strand breaks (dsb), but the exact …

Purpose: It has been shown previously that sensitivity to the induction of chromosome
damage by ionizing radiation is, on average, higher in G2 or G0 lymphocytes of breast …

Enhanced sensitivity to the chromosome-damaging effects of ionizing radiation is a feature
of many cancer-predisposing conditions. We previously showed that 42% of an unselected …

Women with breast cancer and a family history of breast cancer and some with sporadic
breast cancer are deficient in the repair of radiation-induced DNA damage compared with …

The frequencies of chromatid breaks and gaps in metaphase cells fixed 2 h after G2 phase X-
irradiation (1 Gy) were in almost all cases at least two-to three-fold higher in skin fibroblasts …

Cells derived from individuals with ataxia-telangiectasia (AT) are more sensitive to ionizing
radiation and radiomimetic drugs, as evidenced by decreased survival and increased …

Purpose: To evaluate the relationship between radiation-induced cell survival and DNA
damage in primary human fibroblasts to decide whether the initial or residual DNA damage …

Publisher Summary This chapter describes the damage to DNA and chromatin structure
from ionizing radiations, and the radiation sensitivities of mammalian cells. With regard to …

Skin fibroblasts from ataxia telangiectasia (AT) patients, obligate AT heterozygotes (ATH)
and normal individuals were studied for colony-forming ability and repair of DNA double …

The object of this study was to determine whether ataxia-telangiectasia (AT) cells are more
sensitive than normal cells to reduced oxygen species generated either during normal cell …