[HTML][HTML] High endothelial venules (HEVs) in immunity, inflammation and cancer

L Blanchard, JP Girard - Angiogenesis, 2021 - Springer
High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

L Steinman - Nature medicine, 2007 - nature.com
For over 35 years, immunologists have divided T-helper (TH) cells into functional subsets. T-
helper type 1 (TH1) cells—long thought to mediate tissue damage—might be involved in the …

[HTML][HTML] Insulin-dependent diabetes mellitus

R Tisch, H McDevitt - Cell, 1996 - cell.com
Insulin-dependent diabetes mellitus (IDDM) is a multifactorial autoimmune disease for which
susceptibility is determined by environmental and genetic factors. Inheritance is polygenic …

Insulin-dependent diabetes mellitus as an autoimmune disease

JF Bach - Endocrine reviews, 1994 - academic.oup.com
DIABETES mellitus is simply defined on the basis of hyperglycemia. It is, however, a highly
heterogeneous disease. A major advance was made in the late 1960s when insulin …

Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation

K Ley, GS Kansas - Nature Reviews Immunology, 2004 - nature.com
The ability to home to extralymphoid tissues, such as the skin, lungs and gut, is acquired by
many effector and memory T cells after initial antigen encounter. This review discusses the …

[HTML][HTML] Role of sulfatide in normal and pathological cells and tissues

T Takahashi, T Suzuki - Journal of lipid research, 2012 - ASBMB
Sulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide
galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically …

T cell memory

RW Dutton, LM Bradley, SL Swain - Annual review of …, 1998 - annualreviews.org
▪ Abstract Immunological memory can be defined as the faster and stronger response of an
animal that follows reexposure to the same antigen. By this definition, it is an operational …

High endothelial venules (HEVs): specialized endothelium for lymphocyte migration

JP Girard, TA Springer - Immunology today, 1995 - cell.com
High endothelial venules (HEVs? are specialized postcapillary venules found in lymphoid
tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean …

Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab

L Steinman - Nature reviews Drug discovery, 2005 - nature.com
Immunologists have long hypothesized that particular'molecular addresses' govern
lymphocyte entry to a given organ. In 1992, α4β1 integrin was identified as the key molecule …

The selectins and their ligands

SD Rosen, CR Bertozzi - Current opinion in cell biology, 1994 - Elsevier
The selectins are a family of carbohydrate-binding proteins, or lectins, that have stimulated
tremendous interest because of their involvement in a wide array of interactions between …