High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

For over 35 years, immunologists have divided T-helper (TH) cells into functional subsets. T-
helper type 1 (TH1) cells—long thought to mediate tissue damage—might be involved in the …

Insulin-dependent diabetes mellitus (IDDM) is a multifactorial autoimmune disease for which
susceptibility is determined by environmental and genetic factors. Inheritance is polygenic …

DIABETES mellitus is simply defined on the basis of hyperglycemia. It is, however, a highly
heterogeneous disease. A major advance was made in the late 1960s when insulin …

The ability to home to extralymphoid tissues, such as the skin, lungs and gut, is acquired by
many effector and memory T cells after initial antigen encounter. This review discusses the …

Sulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide
galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically …

▪ Abstract Immunological memory can be defined as the faster and stronger response of an
animal that follows reexposure to the same antigen. By this definition, it is an operational …

High endothelial venules (HEVs? are specialized postcapillary venules found in lymphoid
tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean …

Immunologists have long hypothesized that particular'molecular addresses' govern
lymphocyte entry to a given organ. In 1992, α4β1 integrin was identified as the key molecule …

The selectins are a family of carbohydrate-binding proteins, or lectins, that have stimulated
tremendous interest because of their involvement in a wide array of interactions between …