Distraction osteogenesis has become a mainstay in bone tissue engineering and has
significantly improved our armamentarium for reconstructive craniomaxillofacial procedures …

The bony biochemical environment is an active and dynamic system that permits and
promotes cellular functions that lead to matrix production and ossification. Each component …

The role of angiogenesis during mechanically induced bone formation is incompletely
understood. The relationship between the mechanical environment, angiogenesis, and …

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue
engineering. It includes contributions from world-renowned researchers and clinicians who …

Distraction osteogenesis (DO) is a mechanobiological process of regenerating bone tissue
by tension stress. DO is used clinically to lengthen bones or to treat critical size bone …

The distraction osteogenesis (DO) technique has been used worldwide to treat many
complex orthopedic and craniofacial conditions. One limitation of this technique is the long …

Vascular disruption secondary to fracture creates a hypoxic gradient of injury wherein the
oxygen tension at the center of the wound is very low. In vivo this hypoxic microenvironment …

Background: Bone retains regenerative potential into adulthood, and surgeons harness this
plasticity during distraction osteogenesis. The underlying biology governing bone …

BACKGROUND: Distraction osteogenesis is a valuable clinical tool; however the molecular
mechanisms governing successful distraction remain unknown. We have used a uniaxial in …

While it has been long appreciated that biomechanical forces are involved in bone
remodeling and repair, the actual mechanism by which a physical force is translated to the …