Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

Epidemiologic, clinical, and molecular evidence suggest that aging is a major contributor to
the increasing incidence of acute kidney injury and chronic kidney disease. The aging …

Objective: To evaluate the interaction of donor and recipient age on transplant outcome and
immune response. Summary Background Data: The age of donor and recipient is becoming …

The process of normal aging affects organ homeostasis as well as responses to acute and
chronic injury. In view of the rapid growth in the elderly population, it is increasingly …

Despite the considerable amount of data available on the effect of donor age upon the
outcomes of organ transplantation, these still represent an underutilized resource in aging …

Donor age is a major risk factor for allograft outcome in kidney transplantation. The
underlying cellular mechanisms and the recipient's immune response within an aged …

Autophagy is the cell biology process in which cytoplasmic components are degraded in
lysosomes to maintain cellular homeostasis and energy production. In the healthy kidney …

The growing gap between demand and supply for kidney transplants has led to renewed
interest in the use of expanded criteria donor (ECD) kidneys in an effort to increase the …

The critical shortage of organs available for renal transplantation has led to the
consideration of alternative strategies for increasing the donor pool. Recently, the cadaveric …

Donor organ shortage still remains a serious obstacle for the access of wait-list patients to
kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand …