Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

Ligand density on nanoparticles: A parameter with critical impact on nanomedicine

AM Alkilany, L Zhu, H Weller, A Mews, WJ Parak… - Advanced Drug Delivery …, 2019 - Elsevier
Nanoparticles modified with ligands for specific targeting towards receptors expressed on
the surface of target cells are discussed in literature towards improved delivery strategies. In …

Density of conjugated antibody determines the extent of Fc receptor dependent capture of nanoparticles by liver sinusoidal endothelial cells

C Kappel, C Seidl, C Medina-Montano, M Schinnerer… - ACS …, 2021 - ACS Publications
Despite considerable progress in the design of multifunctionalized nanoparticles (NPs) that
selectively target specific cell types, their systemic application often results in unwanted liver …

[HTML][HTML] A quantitative view on multivalent nanomedicine targeting

L Woythe, NB Tito, L Albertazzi - Advanced drug delivery reviews, 2021 - Elsevier
Although the concept of selective delivery has been postulated over 100 years ago, no
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …

Automation and data-driven design of polymer therapeutics

R Upadhya, S Kosuri, M Tamasi, TA Meyer… - Advanced drug delivery …, 2021 - Elsevier
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …

[HTML][HTML] Multivalent protein-drug conjugates–An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells

N Porębska, K Ciura, A Chorążewska… - Biotechnology …, 2023 - Elsevier
With almost 20 million new cases per year, cancer constitutes one of the most important
challenges for public health systems. Unlike traditional chemotherapy, targeted anti-cancer …

Designer peptide and protein dendrimers: a cross-sectional analysis

R Sapra, RP Verma, GP Maurya, S Dhawan… - Chemical …, 2019 - ACS Publications
Dendrimers have attracted immense interest in science and technology due to their unique
chemical structure that offers a myriad of opportunities for researchers. Dendritic design …

Polymer nanomedicines

J Kopeček, J Yang - Advanced drug delivery reviews, 2020 - Elsevier
Polymer nanomedicines (macromolecular therapeutics, polymer-drug conjugates, drug-free
macromolecular therapeutics) are a group of biologically active compounds that are …

[HTML][HTML] Carbohydrate supramolecular chemistry: Beyond the multivalent effect

M González-Cuesta, CO Mellet… - Chemical …, 2020 - pubs.rsc.org
It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …

Biomedical nanoparticle design: What we can learn from viruses

SM Figueroa, D Fleischmann, A Goepferich - Journal of Controlled Release, 2021 - Elsevier
Viruses are nanomaterials with a number of properties that surpass those of many synthetic
nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered …