Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …
ongoing research area that started before these versatile nanoparticles were successfully …
Ligand density on nanoparticles: A parameter with critical impact on nanomedicine
Nanoparticles modified with ligands for specific targeting towards receptors expressed on
the surface of target cells are discussed in literature towards improved delivery strategies. In …
the surface of target cells are discussed in literature towards improved delivery strategies. In …
Density of conjugated antibody determines the extent of Fc receptor dependent capture of nanoparticles by liver sinusoidal endothelial cells
C Kappel, C Seidl, C Medina-Montano, M Schinnerer… - ACS …, 2021 - ACS Publications
Despite considerable progress in the design of multifunctionalized nanoparticles (NPs) that
selectively target specific cell types, their systemic application often results in unwanted liver …
selectively target specific cell types, their systemic application often results in unwanted liver …
[HTML][HTML] A quantitative view on multivalent nanomedicine targeting
Although the concept of selective delivery has been postulated over 100 years ago, no
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …
Automation and data-driven design of polymer therapeutics
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …
structural parameters such as length, composition, architecture, and valency. To facilitate …
[HTML][HTML] Multivalent protein-drug conjugates–An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells
N Porębska, K Ciura, A Chorążewska… - Biotechnology …, 2023 - Elsevier
With almost 20 million new cases per year, cancer constitutes one of the most important
challenges for public health systems. Unlike traditional chemotherapy, targeted anti-cancer …
challenges for public health systems. Unlike traditional chemotherapy, targeted anti-cancer …
Designer peptide and protein dendrimers: a cross-sectional analysis
Dendrimers have attracted immense interest in science and technology due to their unique
chemical structure that offers a myriad of opportunities for researchers. Dendritic design …
chemical structure that offers a myriad of opportunities for researchers. Dendritic design …
[HTML][HTML] Carbohydrate supramolecular chemistry: Beyond the multivalent effect
M González-Cuesta, CO Mellet… - Chemical …, 2020 - pubs.rsc.org
It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …
dramatically, thereby modulating the capacity of carbohydrates to participate in …
Biomedical nanoparticle design: What we can learn from viruses
SM Figueroa, D Fleischmann, A Goepferich - Journal of Controlled Release, 2021 - Elsevier
Viruses are nanomaterials with a number of properties that surpass those of many synthetic
nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered …
nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered …