Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era

M Kostakioti, M Hadjifrangiskou… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Biofilm formation constitutes an alternative lifestyle in which microorganisms adopt a
multicellular behavior that facilitates and/or prolongs survival in diverse environmental …

Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome

SK Russell, JK Harrison, BS Olson, HJ Lee… - Nature …, 2023 - nature.com
Previous urinary tract infections (UTIs) can predispose one to future infections; however, the
underlying mechanisms affecting recurrence are poorly understood. We previously found …

Urinary Tract Infections Caused by Uropathogenic Escherichia coli: Mechanisms of Infection and Treatment Options

Y Zhou, Z Zhou, L Zheng, Z Gong, Y Li, Y Jin… - International journal of …, 2023 - mdpi.com
Urinary tract infections (UTIs) are common bacterial infections that represent a severe public
health problem. They are often caused by Escherichia coli (E. coli), Klebsiella pneumoniae …

Host–pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection

TJ Hannan, M Totsika, KJ Mansfield… - FEMS microbiology …, 2012 - academic.oup.com
Bladder infections affect millions of people yearly, and recurrent symptomatic infections
(cystitis) are very common. The rapid increase in infections caused by multidrug-resistant …

FimH and anti-adhesive therapeutics: a disarming strategy against uropathogens

M Sarshar, P Behzadi, C Ambrosi, C Zagaglia… - Antibiotics, 2020 - mdpi.com
Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that
allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic …

Escherichia coli from animal reservoirs as a potential source of human extraintestinal pathogenic E. coli

L Bélanger, A Garenaux, J Harel… - FEMS Immunology & …, 2011 - academic.oup.com
Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) are an important cause of
urinary tract infections, neonatal meningitis and septicaemia in humans. Animals are …

Treatment and prevention of urinary tract infection with orally active FimH inhibitors

CK Cusumano, JS Pinkner, Z Han, SE Greene… - Science translational …, 2011 - science.org
Chronic and recurrent urinary tract infections pose a serious medical problem because there
are few effective treatment options. Patients with chronic urinary tract infections are …

Anatomy and physiology of the urinary tract: relation to host defense and microbial infection

DR Hickling, TT Sun, XR Wu - Urinary tract infections …, 2017 - Wiley Online Library
The mammalian urinary tract is a contiguous hollow‐organ system whose primary function is
to collect, transport, store, and expel urine periodically and in a highly coordinated fashion …

Drug and vaccine development for the treatment and prevention of urinary tract infections

VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …