Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies
RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …
threatening. The continued emergence of antibiotic resistance, together with our increasing …
Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era
M Kostakioti, M Hadjifrangiskou… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Biofilm formation constitutes an alternative lifestyle in which microorganisms adopt a
multicellular behavior that facilitates and/or prolongs survival in diverse environmental …
multicellular behavior that facilitates and/or prolongs survival in diverse environmental …
Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome
SK Russell, JK Harrison, BS Olson, HJ Lee… - Nature …, 2023 - nature.com
Previous urinary tract infections (UTIs) can predispose one to future infections; however, the
underlying mechanisms affecting recurrence are poorly understood. We previously found …
underlying mechanisms affecting recurrence are poorly understood. We previously found …
Urinary Tract Infections Caused by Uropathogenic Escherichia coli: Mechanisms of Infection and Treatment Options
Y Zhou, Z Zhou, L Zheng, Z Gong, Y Li, Y Jin… - International journal of …, 2023 - mdpi.com
Urinary tract infections (UTIs) are common bacterial infections that represent a severe public
health problem. They are often caused by Escherichia coli (E. coli), Klebsiella pneumoniae …
health problem. They are often caused by Escherichia coli (E. coli), Klebsiella pneumoniae …
Host–pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection
Bladder infections affect millions of people yearly, and recurrent symptomatic infections
(cystitis) are very common. The rapid increase in infections caused by multidrug-resistant …
(cystitis) are very common. The rapid increase in infections caused by multidrug-resistant …
FimH and anti-adhesive therapeutics: a disarming strategy against uropathogens
Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that
allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic …
allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic …
Escherichia coli from animal reservoirs as a potential source of human extraintestinal pathogenic E. coli
Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) are an important cause of
urinary tract infections, neonatal meningitis and septicaemia in humans. Animals are …
urinary tract infections, neonatal meningitis and septicaemia in humans. Animals are …
Treatment and prevention of urinary tract infection with orally active FimH inhibitors
CK Cusumano, JS Pinkner, Z Han, SE Greene… - Science translational …, 2011 - science.org
Chronic and recurrent urinary tract infections pose a serious medical problem because there
are few effective treatment options. Patients with chronic urinary tract infections are …
are few effective treatment options. Patients with chronic urinary tract infections are …
Anatomy and physiology of the urinary tract: relation to host defense and microbial infection
DR Hickling, TT Sun, XR Wu - Urinary tract infections …, 2017 - Wiley Online Library
The mammalian urinary tract is a contiguous hollow‐organ system whose primary function is
to collect, transport, store, and expel urine periodically and in a highly coordinated fashion …
to collect, transport, store, and expel urine periodically and in a highly coordinated fashion …
Drug and vaccine development for the treatment and prevention of urinary tract infections
VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …