S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in
metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group …

Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and
diverse family of natural products. They possess interesting biological properties such as …

Many cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM)
methyltransferases have been identified through sequence alignment and/or genetic …

Radical SAM enzymes involved in the biosynthesis of ribosomally synthesized and post-
translationally modified peptides catalyze unusual transformations that lead to unique …

Covering: 2011 to 2018 This highlight summarizes the investigation of cobalamin (Cbl)-and
radical S-adenosyl-L-methionine (SAM)-dependent enzymes found in natural product …

2-Hydroxyphenylthiazolines are a family of iron-chelating nonribosomal peptide natural
products that function as virulence-conferring siderophores in various Gram-negative …

Fom3, the antepenultimate enzyme in the fosfomycin biosynthetic pathway in Streptomyces
spp., is a class B cobalamin-dependent radical SAM methyltransferase that catalyzes …

HemN is a radical S-adenosylmethionine (SAM) enzyme that catalyzes the anaerobic
oxidative decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX, a key …

Complex carbapenem β-lactam antibiotics contain diverse C6 alkyl substituents constructed
by cobalamin-dependent radical SAM enzymes. TokK installs the C6 isopropyl chain found …

S‐Adenosylmethionine (SAM) is one of the most common co‐substrates in enzyme‐
catalyzed methylation reactions. Most SAM‐dependent reactions proceed through an SN2 …