Principles of nanoparticle formation by flash nanoprecipitation

WS Saad, RK Prud'homme - Nano Today, 2016 - Elsevier
Rapid precipitation is an efficient approach for engineering materials at the nanoscale. By
controlling solute nucleation and growth rates in solvent precipitation processes, the size of …

Control of polymeric nanoparticle size to improve therapeutic delivery

JW Hickey, JL Santos, JM Williford, HQ Mao - Journal of Controlled …, 2015 - Elsevier
As nanoparticle (NP)-mediated drug delivery research continues to expand, understanding
parameters that govern NP interactions with the biological environment becomes …

Current developments and applications of microfluidic technology toward clinical translation of nanomedicines

D Liu, H Zhang, F Fontana, JT Hirvonen… - Advanced drug delivery …, 2018 - Elsevier
Nanoparticulate drug delivery systems hold great potential for the therapy of many diseases,
especially cancer. However, the translation of nanoparticulate drug delivery systems from …

Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses

M Liu, AR Khan, J Ji, G Lin, X Zhao, G Zhai - Journal of Controlled Release, 2018 - Elsevier
Sonodynamic therapy (SDT) has been proposed as a new modality for cancer management
through low-intensity ultrasound induced activation of sonosensitizers. Here, we designed a …

Designing polymers with sugar-based advantages for bioactive delivery applications

Y Zhang, JW Chan, A Moretti, KE Uhrich - Journal of Controlled Release, 2015 - Elsevier
Sugar-based polymers have been extensively explored as a means to increase drug
delivery systems' biocompatibility and biodegradation. Here, we review the use of sugar …

Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy

M Song, W Xia, Z Tao, B Zhu, W Zhang, C Liu… - Drug Delivery, 2021 - Taylor & Francis
Malignant melanoma is a life-threatening form of skin cancer with a low response rate to
single-agent chemotherapy. Although combined therapies of metformin (MET) and …

Flash technology-based self-assembly in nanoformulation: Fabrication to biomedical applications

H Hu, C Yang, M Li, D Shao, HQ Mao, KW Leong - Materials Today, 2021 - Elsevier
Advances in nanoformulation have driven progress in biomedicine by producing nanoscale
tools for biosensing, imaging, and drug delivery. Flash-based technology, the combination of …

Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo

DR Lewis, LK Petersen, AW York… - Proceedings of the …, 2015 - National Acad Sciences
Atherosclerosis, the build-up of occlusive, lipid-rich plaques in arterial walls, is a focal trigger
of chronic coronary, intracranial, and peripheral arterial diseases, which together account for …

Nanomedicine-based strategies for treatment of atherosclerosis

M Schiener, M Hossann, JR Viola… - Trends in molecular …, 2014 - cell.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall that arises from an
imbalanced lipid metabolism and a maladaptive inflammatory response. Despite intensive …

Sugar-based amphiphilic polymers for biomedical applications: from nanocarriers to therapeutics

L Gu, A Faig, D Abdelhamid… - Accounts of chemical …, 2014 - ACS Publications
Conspectus Various therapeutics exhibit unfavorable physicochemical properties or stability
issues that reduce their in vivo efficacy. Therefore, carriers able to overcome such …