Pancreatic islet transplantation in humans: recent progress and future directions

MR Rickels, RP Robertson - Endocrine reviews, 2019 - academic.oup.com
Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Allo Beta Cell transplantation: specific features, unanswered questions, and immunological challenge

R Caldara, V Tomajer, P Monti, V Sordi, A Citro… - Frontiers in …, 2023 - frontiersin.org
Type 1 diabetes (T1D) presents a persistent medical challenge, demanding innovative
strategies for sustained glycemic control and enhanced patient well-being. Beta cells are …

Infection with SARS-CoV-2 can cause pancreatic impairment

W Deng, L Bao, Z Song, L Zhang, P Yu, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Evidence suggests associations between COVID-19 patients or vaccines and
glycometabolic dysfunction and an even higher risk of the occurrence of diabetes. Herein …

[HTML][HTML] Diagnosis and treatment of allograft rejection in islet transplantation

CP Landstra, MF Nijhoff, DL Roelen… - American Journal of …, 2023 - Elsevier
Islet transplantation stabilizes glycemic control in patients with complicated diabetes
mellitus. Rapid functional decline could be due to islet allograft rejection. However, there is …

Function and composition of pancreatic islet cell implants in omentum of type 1 diabetes patients

F Van Hulle, K De Groot, R Hilbrands… - American Journal of …, 2022 - Wiley Online Library
Intraportal (IP) islet cell transplants can restore metabolic control in type 1 diabetes patients,
but limitations raise the need for establishing a functional beta cell mass (FBM) in a confined …

Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

W Staels, Y Verdonck, Y Heremans, G Leuckx… - Diabetologia, 2018 - Springer
Aims/hypothesis The initial avascular period following islet transplantation seriously
compromises graft function and survival. Enhancing graft revascularisation to improve …

Current issues in allogeneic islet transplantation

CA Chang, MC Lawrence… - Current opinion in organ …, 2017 - journals.lww.com
Allogeneic islet transplantation has vastly improved over the past two decades. Success in
restoration of glycemic control and hypoglycemic awareness after islet transplantation has …

Accessory cells for β‐cell transplantation

W Staels, S De Groef, Y Heremans… - Diabetes, Obesity …, 2016 - Wiley Online Library
Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes
mellitus with persistent risk of glycaemic alterations and life‐threatening complications …

Combined analysis of GAD65, miR-375, and unmethylated insulin DNA following islet transplantation in patients with T1D

S Roels, OR Costa, SA Tersey, G Stange… - The Journal of …, 2019 - academic.oup.com
Aim Several biomarkers have been proposed to detect pancreatic β cell destruction in vivo
but so far have not been compared for sensitivity and significance. Methods We used islet …

Evaluation and management of ketosis-prone diabetes

R Gaba, P Mehta… - Expert review of …, 2019 - Taylor & Francis
Introduction: Patients presenting with diabetic ketoacidosis (DKA) who lack the classic
phenotype of autoimmune type 1 diabetes have become increasingly identified in recent …