Calcium signalling in T cells
M Trebak, JP Kinet - Nature Reviews Immunology, 2019 - nature.com
Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …
Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Calcium signaling in smooth muscle
DC Hill-Eubanks, ME Werner… - Cold Spring …, 2011 - cshperspectives.cshlp.org
Changes in intracellular Ca2+ are central to the function of smooth muscle, which lines the
walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide …
walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide …
Creating order from chaos: cellular regulation by kinase anchoring
Second messenger responses rely on where and when the enzymes that propagate these
signals become active. Spatial and temporal organization of certain signaling enzymes is …
signals become active. Spatial and temporal organization of certain signaling enzymes is …
Calcium channels in vascular smooth muscle
Abstract Calcium (Ca 2+) plays a central role in excitation, contraction, transcription, and
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
Calcium dynamics in vascular smooth muscle
Smooth muscle cells are ultimately responsible for determining vascular luminal diameter
and blood flow. Dynamic changes in intracellular calcium are a critical mechanism …
and blood flow. Dynamic changes in intracellular calcium are a critical mechanism …
A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation–transcription coupling
Y Suzuki, T Ozawa, T Kurata… - Proceedings of the …, 2022 - National Acad Sciences
Elevation of intracellular Ca2+ concentration ([Ca2+] i) activates Ca2+/calmodulin-
dependent kinases (CaMK) and promotes gene transcription. This signaling pathway is …
dependent kinases (CaMK) and promotes gene transcription. This signaling pathway is …