Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

No metazoan cell survives on its own, absent the signals and support of its milieu. For
multicellular life with specialized tissues to persist, organization is everything and so …

The mechanisms contributing to sarcopenia include reduced satellite cell (myogenic stem
cell) function that is impacted by the environment (niche) of these cells. Satellite cell function …

Many existing clinical treatments are limited in their ability to completely restore decreased
or lost tissue and organ function, an unenviable situation only further exacerbated by a …

TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …

Ischemia-reperfusion injury (I/RI), produced by an initial interruption of organ blood flow and
its subsequent restoration, contributes significantly to the pathophysiologies of stroke …

There is currently no cure for muscular dystrophies, although several promising strategies
are in basic and clinical research. One such strategy is cell transplantation with satellite cells …

Amniotic fluid-derived mesenchymal stem cells (AF-MSC) are newly described, excellent
seed cells that have good differentiation capability and are convenient to obtain. However, it …

The T-box factors belong to an ancient protein family, which comprises a cluster of
evolutionarily-conserved transcription factors that regulate gene expression and that are …

Adult stem cells occupy a niche that contributes to their function, but how stem cells rebuild
their microenvironment after injury remains an open‐ended question. Herein, biomaterial …