A guide for assessment of myocardial stiffness in health and disease

JC Villalobos Lizardi, J Baranger, MB Nguyen… - Nature Cardiovascular …, 2022 - nature.com
Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic
and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to …

Advances in computational modelling for personalised medicine after myocardial infarction

K Mangion, H Gao, D Husmeier, X Luo, C Berry - Heart, 2018 - heart.bmj.com
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide.
Determining which patients will experience heart failure and sudden cardiac death after an …

[HTML][HTML] Comparative analysis of nonlinear viscoelastic models across common biomechanical experiments

W Zhang, A Capilnasiu, D Nordsletten - Journal of Elasticity, 2021 - Springer
Biomechanical modeling has a wide range of applications in the medical field, including in
diagnosis, treatment planning and tissue engineering. The key to these predictive models …

An efficient and accurate method for modeling nonlinear fractional viscoelastic biomaterials

W Zhang, A Capilnasiu, G Sommer… - Computer methods in …, 2020 - Elsevier
Computational biomechanics plays an important role in biomedical engineering: using
modeling to understand pathophysiology, treatment and device design. While experimental …

Soft robotic artificial left ventricle simulator capable of reproducing myocardial biomechanics

J Davies, MT Thai, B Sharma, TT Hoang… - Science Robotics, 2024 - science.org
The heart's intricate myocardial architecture has been called the Gordian knot of anatomy,
an impossible tangle of intricate muscle fibers. This complexity dictates equally complex …

[HTML][HTML] An implementation of patient-specific biventricular mechanics simulations with a deep learning and computational pipeline

R Miller, E Kerfoot, C Mauger, TF Ismail… - Frontiers in …, 2021 - frontiersin.org
Parameterised patient-specific models of the heart enable quantitative analysis of cardiac
function as well as estimation of regional stress and intrinsic tissue stiffness. However, the …

Left ventricular diastolic myocardial stiffness and end-diastolic myofibre stress in human heart failure using personalised biomechanical analysis

ZJ Wang, VY Wang, CP Bradley, MP Nash… - Journal of …, 2018 - Springer
Understanding the aetiology of heart failure with preserved (HFpEF) and reduced (HFrEF)
ejection fraction requires knowledge of biomechanical factors such as diastolic myocardial …

The effects of viscoelasticity on residual strain in aortic soft tissues

W Zhang, G Sommer, JA Niestrawska, GA Holzapfel… - Acta Biomaterialia, 2022 - Elsevier
Residual stress is thought to play a critical role in modulating stress distributions in soft
biological tissues and in maintaining the mechanobiological stress environment of cells …

Gaussian process emulation to accelerate parameter estimation in a mechanical model of the left ventricle: a critical step towards clinical end-user relevance

U Noè, A Lazarus, H Gao, V Davies… - Journal of the …, 2019 - royalsocietypublishing.org
In recent years, we have witnessed substantial advances in the mathematical modelling of
the biomechanical processes underlying the dynamics of the cardiac soft-tissue. Gao et …

[HTML][HTML] Modelling of fibre dispersion and its effects on cardiac mechanics from diastole to systole

D Guan, X Zhuan, W Holmes, X Luo, H Gao - Journal of Engineering …, 2021 - Springer
Detailed fibre architecture plays a crucial role in myocardial mechanics both passively and
actively. Strong interest has been attracted over decades in mathematical modelling of …