Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Prolactinomas account for approximately 40% of all pituitary adenomas and are an
important cause of hypogonadism and infertility. The ultimate goal of therapy for …

Pituitary adenomas may hypersecrete hormones (including prolactin, growth hormone and
adrenocorticotropic hormone, and rarely follicle-stimulating hormone, luteinizing hormone or …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …

Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of
mutations conferring aggressive or drug-resistant phenotypes during cancer evolution …

Pituitary tumor-transforming gene-1 (PTTG1) is overexpressed in a variety of endocrine-
related tumors, especially pituitary, thyroid, breast, ovarian, and uterine tumors, as well as …

Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA
and regulates telomerase activity, are associated with ribosomal dysfunction and increased …

Drivers of sporadic benign pituitary adenoma growth are largely unknown. Whole-exome
sequencing of 159 prospectively resected pituitary adenomas showed that somatic copy …

Background The pituitary tumour transforming gene (pttg) plays a central role in pituitary
tumorigenesis, but PTTG protein expression is poorly documented and its relationship with …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …