Elucidating the molecular architecture of adaptation via evolve and resequence experiments
Evolve and resequence (E&R) experiments use experimental evolution to adapt populations
to a novel environment, then next-generation sequencing to analyse genetic changes. They …
to a novel environment, then next-generation sequencing to analyse genetic changes. They …
The fascinating and secret wild life of the budding yeast S. cerevisiae
G Liti - Elife, 2015 - elifesciences.org
The budding yeast Saccharomyces cerevisiae has been used in laboratory experiments for
over a century and has been instrumental in understanding virtually every aspect of …
over a century and has been instrumental in understanding virtually every aspect of …
A high-definition view of functional genetic variation from natural yeast genomes
The question of how genetic variation in a population influences phenotypic variation and
evolution is of major importance in modern biology. Yet much is still unknown about the …
evolution is of major importance in modern biology. Yet much is still unknown about the …
Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast
Mapping the genetic basis of complex traits is critical to uncovering the biological
mechanisms that underlie disease and other phenotypes. Genome-wide association studies …
mechanisms that underlie disease and other phenotypes. Genome-wide association studies …
Standing Genetic Variation Drives Repeatable Experimental Evolution in Outcrossing Populations of Saccharomyces cerevisiae
Abstract In “evolve-and-resequence”(E&R) experiments, whole-genome sequence data from
laboratory-evolved populations can potentially uncover mechanisms of adaptive change …
laboratory-evolved populations can potentially uncover mechanisms of adaptive change …
Experimental evolution of yeast for high-temperature tolerance
Thermotolerance is a polygenic trait that contributes to cell survival and growth under
unusually high temperatures. Although some genes associated with high-temperature …
unusually high temperatures. Although some genes associated with high-temperature …
Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population
GR Keele - G3: Genes, Genomes, Genetics, 2023 - academic.oup.com
Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
Identification of genetic variants of the industrial yeast Komagataella phaffii (Pichia pastoris) that contribute to increased yields of secreted heterologous proteins
The yeast Komagataella phaffii (formerly called Pichia pastoris) is used widely as a host for
secretion of heterologous proteins, but only a few isolates of this species exist and all the …
secretion of heterologous proteins, but only a few isolates of this species exist and all the …
The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae
Abstract Loss‐of‐function (LoF) mutations associated with disease do not manifest equally
in different individuals. The impact of the genetic background on the consequences of LoF …
in different individuals. The impact of the genetic background on the consequences of LoF …
Evolutionary engineering to enhance starter culture performance in food fermentations
Highlights•Next-generation sequencing has a huge impact on evolutionary
engineering.•Novel selection approaches include yield selection and single-cell …
engineering.•Novel selection approaches include yield selection and single-cell …