Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele
nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

Facilitated transport is necessitated for large size, charged, and/or hydrophilic drugs to move
across the membrane. The drug transporters in the solute carrier (SLC) superfamily, mainly …

Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …

Robust, reliable quantification of large sample cohorts is often essential for meaningful
clinical or pharmaceutical proteomics investigations, but it is technically challenging. When …

Drug-induced liver injury (DILI) is the leading cause of acute liver failure and a major
concern in drug development. Altered bile acid homeostasis via inhibition of the bile salt …

Tyrosine phosphorylation is a crucial posttranslational modification that is involved in
various aspects of cell biology and often has functions in cancers. It is necessary not only to …