Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …

Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not
completely curative, and thus enormously unfulfilled challenges. With the in‐depth studies of …

Tissue engineered constructs have the potential to respond to the unmet medical need of
treating deep osteochondral defects. However, current tissue engineering strategies …

Clinical therapeutics for the regeneration of osteochondral defects (OCD) in the early stages
of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of …

Background Periosteum is a vascularized tissue membrane covering the bone surface and
plays a decisive role in bone reconstruction process after fracture. Various artificial …

Tissue-engineered graft substitutes have shown great potential to treat large bone defects.
While we usually assume that therapeutic approaches developed for appendicular bone …

Repair and regeneration of articular cartilage lesions have always been a major challenge
in the medical field due to its peculiar structure (eg, sparsely distributed chondrocytes, no …

Because of the low self-healing capacity of articular cartilage, cartilage injuries and
degenerations triggered by various diseases are almost irreversible. Previous studies have …

Over centuries, several advances have been made in osteochondral (OC) tissue
engineering to regenerate more biomimetic tissue. As an essential component of tissue …

It is challenging to develop a biphasic scaffold with biomimetic compositional, structural, and
functional properties to achieve concomitant repair of both superficial cartilage and …