The host cell membrane-associated RING-CH 8 protein (MARCH8), a member of the E3
ubiquitin ligase family, regulates intracellular turnover of many transmembrane proteins and …

Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped
viruses budding and release from the producer cells, viral envelope glycoproteins are …

Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has led to an unprecedented public health crisis worldwide. Though the host …

Abstract Membrane‐associated RING‐CH (MARCH) family proteins were recently reported
to inhibit viral replication through multiple modes. Previous work showed that human …

The type 1 interferon-regulated E3 ubiquitin ligase MARCH1 reduces surface expression of
HIV-1 envelope glycoproteins (Env) and their packaging into nascent virions, a condition …

Highlights•Gene duplications expand the repertoire of antiretroviral host factors.•Duplication
of antiretroviral proteins increases the barrier to viral counteraction.•Restriction factor …

The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that
downregulates various host transmembrane proteins, such as MHC-II. We have recently …

The human genome is estimated to encode more than 500 proteases performing a wide
range of important physiological functions. They digest proteins in our food, determine the …

The pandemic coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), is currently the most formidable challenge to …

Macroautophagy/autophagy activation in renal tubular epithelial cells protects against acute
kidney injury (AKI). However, the role of immune cell autophagy, such as that involving …