Bats and coronaviruses
Bats are speculated to be reservoirs of several emerging viruses including coronaviruses
(CoVs) that cause serious disease in humans and agricultural animals. These include CoVs …
(CoVs) that cause serious disease in humans and agricultural animals. These include CoVs …
[HTML][HTML] Nidovirus RNA polymerases: complex enzymes handling exceptional RNA genomes
CC Posthuma, AJW Te Velthuis, EJ Snijder - Virus research, 2017 - Elsevier
Coronaviruses and arteriviruses are distantly related human and animal pathogens that
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …
Coronaviruses
Five swine coronaviruses (CoVs) have been identified: transmissible gastroenteritis virus
(TGEV) first described in 1946; porcine respiratory coronavirus (PRCV), a spike (S) gene …
(TGEV) first described in 1946; porcine respiratory coronavirus (PRCV), a spike (S) gene …
An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine
Y Li, Q Wu, L Huang, C Yuan, J Wang… - Nature communications, 2018 - nature.com
Porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry.
Although the fecal–oral route is generally accepted, an increased number of reports indicate …
Although the fecal–oral route is generally accepted, an increased number of reports indicate …
Deletion of a 197-amino-acid region in the N-terminal domain of spike protein attenuates porcine epidemic diarrhea virus in piglets
We previously isolated a porcine epidemic diarrhea virus (PEDV) strain, PC177, by blind
serial passaging of the intestinal contents of a diarrheic piglet in Vero cell culture. Compared …
serial passaging of the intestinal contents of a diarrheic piglet in Vero cell culture. Compared …
Inhibition of porcine epidemic diarrhea virus replication and viral 3C-like protease by quercetin
Z Li, H Cao, Y Cheng, X Zhang, W Zeng, Y Sun… - International Journal of …, 2020 - mdpi.com
For the last decade, porcine epidemic diarrhea virus (PEDV) variant strains have caused
severe damage to the global pig industry. Until now, no effective antivirals have been …
severe damage to the global pig industry. Until now, no effective antivirals have been …
Glycyrrhizin inhibits PEDV infection and proinflammatory cytokine secretion via the HMGB1/TLR4-MAPK p38 pathway
R Gao, Y Zhang, Y Kang, W Xu, L Jiang, T Guo… - International journal of …, 2020 - mdpi.com
Our previous study showed that glycyrrhizin (GLY) inhibited porcine epidemic diarrhea virus
(PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear. In this study …
(PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear. In this study …
[HTML][HTML] Hypericin inhibit alpha-coronavirus replication by targeting 3CL protease
Y Zhang, H Chen, M Zou, R Oerlemans, C Shao, Y Ren… - Viruses, 2021 - mdpi.com
The porcine epidemic diarrhea virus (PEDV) is an Alphacoronavirus (α-CoV) that causes
high mortality in infected piglets, resulting in serious economic losses in the farming industry …
high mortality in infected piglets, resulting in serious economic losses in the farming industry …
Emerging highly virulent porcine epidemic diarrhea virus: molecular mechanisms of attenuation and rational design of live attenuated vaccines
The highly virulent porcine epidemic diarrhea virus (PEDV) emerged in China in 2010. It
infects pigs of all ages, and causes severe diarrhea and high mortality rates in newborn …
infects pigs of all ages, and causes severe diarrhea and high mortality rates in newborn …
Quantitative proteomic analysis reveals antiviral and anti-inflammatory effects of puerarin in piglets infected with porcine epidemic diarrhea virus
M Wu, Q Zhang, D Yi, T Wu, H Chen, S Guo… - Frontiers in …, 2020 - frontiersin.org
Porcine epidemic diarrhea virus (PEDV) has caused enormous economic losses to the
swine industry worldwide in recent years. Puerarin (PR), a major isoflavonoid isolated from …
swine industry worldwide in recent years. Puerarin (PR), a major isoflavonoid isolated from …