Bats and coronaviruses

A Banerjee, K Kulcsar, V Misra, M Frieman, K Mossman - Viruses, 2019 - mdpi.com
Bats are speculated to be reservoirs of several emerging viruses including coronaviruses
(CoVs) that cause serious disease in humans and agricultural animals. These include CoVs …

[HTML][HTML] Nidovirus RNA polymerases: complex enzymes handling exceptional RNA genomes

CC Posthuma, AJW Te Velthuis, EJ Snijder - Virus research, 2017 - Elsevier
Coronaviruses and arteriviruses are distantly related human and animal pathogens that
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …

Coronaviruses

LJ Saif, Q Wang, AN Vlasova, K Jung… - Diseases of swine, 2019 - Wiley Online Library
Five swine coronaviruses (CoVs) have been identified: transmissible gastroenteritis virus
(TGEV) first described in 1946; porcine respiratory coronavirus (PRCV), a spike (S) gene …

An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine

Y Li, Q Wu, L Huang, C Yuan, J Wang… - Nature communications, 2018 - nature.com
Porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry.
Although the fecal–oral route is generally accepted, an increased number of reports indicate …

Deletion of a 197-amino-acid region in the N-terminal domain of spike protein attenuates porcine epidemic diarrhea virus in piglets

Y Hou, CM Lin, M Yokoyama, BL Yount… - Journal of …, 2017 - Am Soc Microbiol
We previously isolated a porcine epidemic diarrhea virus (PEDV) strain, PC177, by blind
serial passaging of the intestinal contents of a diarrheic piglet in Vero cell culture. Compared …

Inhibition of porcine epidemic diarrhea virus replication and viral 3C-like protease by quercetin

Z Li, H Cao, Y Cheng, X Zhang, W Zeng, Y Sun… - International Journal of …, 2020 - mdpi.com
For the last decade, porcine epidemic diarrhea virus (PEDV) variant strains have caused
severe damage to the global pig industry. Until now, no effective antivirals have been …

Glycyrrhizin inhibits PEDV infection and proinflammatory cytokine secretion via the HMGB1/TLR4-MAPK p38 pathway

R Gao, Y Zhang, Y Kang, W Xu, L Jiang, T Guo… - International journal of …, 2020 - mdpi.com
Our previous study showed that glycyrrhizin (GLY) inhibited porcine epidemic diarrhea virus
(PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear. In this study …

[HTML][HTML] Hypericin inhibit alpha-coronavirus replication by targeting 3CL protease

Y Zhang, H Chen, M Zou, R Oerlemans, C Shao, Y Ren… - Viruses, 2021 - mdpi.com
The porcine epidemic diarrhea virus (PEDV) is an Alphacoronavirus (α-CoV) that causes
high mortality in infected piglets, resulting in serious economic losses in the farming industry …

Emerging highly virulent porcine epidemic diarrhea virus: molecular mechanisms of attenuation and rational design of live attenuated vaccines

Y Hou, Q Wang - International journal of molecular sciences, 2019 - mdpi.com
The highly virulent porcine epidemic diarrhea virus (PEDV) emerged in China in 2010. It
infects pigs of all ages, and causes severe diarrhea and high mortality rates in newborn …

Quantitative proteomic analysis reveals antiviral and anti-inflammatory effects of puerarin in piglets infected with porcine epidemic diarrhea virus

M Wu, Q Zhang, D Yi, T Wu, H Chen, S Guo… - Frontiers in …, 2020 - frontiersin.org
Porcine epidemic diarrhea virus (PEDV) has caused enormous economic losses to the
swine industry worldwide in recent years. Puerarin (PR), a major isoflavonoid isolated from …