Diverse roles of neurotensin agonists in the central nervous system
M Boules, Z Li, K Smith, P Fredrickson… - Frontiers in …, 2013 - frontiersin.org
Neurotensin (NT) is a tridecapeptide that is found in the central nervous system (CNS) and
the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in …
the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in …
Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation
Substance P (SP) and neurotensin (NT) are neuropeptides isolated in the periphery and in
the central nervous system. They are involved in various regulatory processes in the …
the central nervous system. They are involved in various regulatory processes in the …
Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat …
Stress during postnatal development is associated with an increased risk for depression,
anxiety disorders, and substance abuse later in life, almost as if mental illness is able to be …
anxiety disorders, and substance abuse later in life, almost as if mental illness is able to be …
Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders
MM Boules, P Fredrickson, AM Muehlmann… - Behavioral …, 2014 - mdpi.com
Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to
modulate, dopaminergic and other neurotransmitter systems involved in the …
modulate, dopaminergic and other neurotransmitter systems involved in the …
Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets
G Kyriatzis, M Khrestchatisky, L Ferhat… - Current …, 2024 - ingentaconnect.com
Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed in the CNS that has
been involved in the pathophysiology of many neural and psychiatric disorders. There are …
been involved in the pathophysiology of many neural and psychiatric disorders. There are …
Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats
Neurotensin is an endogenous neuropeptide that has significant interactions with
monoamine neurotransmitter systems. To date, neurotensin NTS 1 receptor agonists, such …
monoamine neurotransmitter systems. To date, neurotensin NTS 1 receptor agonists, such …
Antipsychotic-like effects of a neurotensin receptor type 1 agonist
CA Vadnie, J Ayers-Ringler, A Oliveros… - Behavioural brain …, 2016 - Elsevier
Although neurotensin (NT) analogs are known to produce antipsychotic-like effects, the
therapeutic possibility of a brain penetrant NTS1 agonist in treating psychiatric disorders has …
therapeutic possibility of a brain penetrant NTS1 agonist in treating psychiatric disorders has …
Systemic administration of the neurotensin NTS₁-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown Norway rats.
AA Keiser, KS Matazel, MK Esser, D Feifel… - Experimental and …, 2014 - psycnet.apa.org
Agonists for the neurotensin NTS 1 receptor consistently exhibit antipsychotic effects in
animal models without producing catalepsy, suggesting that NTS 1-receptor agonists may …
animal models without producing catalepsy, suggesting that NTS 1-receptor agonists may …
The Neurotensin NTS1 Receptor Agonist PD149163 Produces Antidepressant‐Like Effects in the Forced Swim Test: Further Support for Neurotensin as a Novel …
ABSTRACT Preclinical Research Neurotensin is a nonbrain penetrant neuropeptide
neurotransmitter that alters dopaminergic and serotonergic neurotransmission. Previous …
neurotransmitter that alters dopaminergic and serotonergic neurotransmission. Previous …
Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation
AL Sharpe, E Varela, MJ Beckstead - PloS one, 2017 - journals.plos.org
Methamphetamine (METH) is a psychostimulant that exhibits significant abuse potential.
Although METH addiction is a major health and societal concern, no drug is currently …
Although METH addiction is a major health and societal concern, no drug is currently …