Diverse roles of neurotensin agonists in the central nervous system

M Boules, Z Li, K Smith, P Fredrickson… - Frontiers in …, 2013 - frontiersin.org
Neurotensin (NT) is a tridecapeptide that is found in the central nervous system (CNS) and
the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in …

Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation

L Lénárd, K László, E Kertes, T Ollmann… - Neuroscience & …, 2018 - Elsevier
Substance P (SP) and neurotensin (NT) are neuropeptides isolated in the periphery and in
the central nervous system. They are involved in various regulatory processes in the …

Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat …

H Toda, S Boku, S Nakagawa, T Inoue, A Kato… - PloS one, 2014 - journals.plos.org
Stress during postnatal development is associated with an increased risk for depression,
anxiety disorders, and substance abuse later in life, almost as if mental illness is able to be …

Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders

MM Boules, P Fredrickson, AM Muehlmann… - Behavioral …, 2014 - mdpi.com
Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to
modulate, dopaminergic and other neurotransmitter systems involved in the …

Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets

G Kyriatzis, M Khrestchatisky, L Ferhat… - Current …, 2024 - ingentaconnect.com
Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed in the CNS that has
been involved in the pathophysiology of many neural and psychiatric disorders. There are …

Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats

AJ Prus, TM Hillhouse, AL LaCrosse - Progress in Neuro …, 2014 - Elsevier
Neurotensin is an endogenous neuropeptide that has significant interactions with
monoamine neurotransmitter systems. To date, neurotensin NTS 1 receptor agonists, such …

Antipsychotic-like effects of a neurotensin receptor type 1 agonist

CA Vadnie, J Ayers-Ringler, A Oliveros… - Behavioural brain …, 2016 - Elsevier
Although neurotensin (NT) analogs are known to produce antipsychotic-like effects, the
therapeutic possibility of a brain penetrant NTS1 agonist in treating psychiatric disorders has …

Systemic administration of the neurotensin NTS₁-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown Norway rats.

AA Keiser, KS Matazel, MK Esser, D Feifel… - Experimental and …, 2014 - psycnet.apa.org
Agonists for the neurotensin NTS 1 receptor consistently exhibit antipsychotic effects in
animal models without producing catalepsy, suggesting that NTS 1-receptor agonists may …

The Neurotensin NTS1 Receptor Agonist PD149163 Produces Antidepressant‐Like Effects in the Forced Swim Test: Further Support for Neurotensin as a Novel …

LM Carey, RJ Rice, AJ Prus - Drug Development Research, 2017 - Wiley Online Library
ABSTRACT Preclinical Research Neurotensin is a nonbrain penetrant neuropeptide
neurotransmitter that alters dopaminergic and serotonergic neurotransmission. Previous …

Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation

AL Sharpe, E Varela, MJ Beckstead - PloS one, 2017 - journals.plos.org
Methamphetamine (METH) is a psychostimulant that exhibits significant abuse potential.
Although METH addiction is a major health and societal concern, no drug is currently …