Co-evolution is a fundamental component of the theory of evolution and is essential for
understanding the relationships between species in complex ecological networks. A wide …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …

INTRODUCTION A disease is rarely a straightforward consequence of an abnormality in a
single gene, but rather reflects the interplay of multiple molecular processes. The …

The protein-protein docking problem is one of the focal points of activity in computational
biophysics and structural biology. The three-dimensional structure of a protein-protein …

The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …

The advent of the “omics” era in biology research has brought new challenges and requires
the development of novel strategies to answer previously intractable questions. Molecular …

Computational modeling of three-dimensional macromolecular structures and complexes
from their sequence has been a long-standing vision in structural biology. Over the last 2 …

Motivation: Statistical potentials have been widely used for modeling whole proteins and
their parts (eg sidechains and loops) as well as interactions between proteins, nucleic acids …

Abstract Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity.
They exert proinflammatory effects by binding a primary receptor that recruits a receptor …

Highlights•We review current resources that organize experimental knowledge of the
interaction space.•We present the latest efforts in the prediction of interactions and the …