Visible‐light‐induced decarboxylative functionalization of carboxylic acids and their derivatives

J Xuan, ZG Zhang, WJ Xiao - … Chemie International Edition, 2015 - Wiley Online Library
Visible‐light‐induced radical decarboxylative functionalization of carboxylic acids and their
derivatives has recently received considerable attention as a novel and efficient method to …

Carboxylic acids as a traceless activation group for conjugate additions: a three-step synthesis of (±)-pregabalin

L Chu, C Ohta, Z Zuo… - Journal of the American …, 2014 - ACS Publications
The direct application of carboxylic acids as a traceless activation group for radical Michael
additions has been accomplished via visible light-mediated photoredox catalysis. Photon …

An update on the stereoselective synthesis of γ-amino acids

M Ordóñez, C Cativiela, I Romero-Estudillo - Tetrahedron: Asymmetry, 2016 - Elsevier
This review outlines the most recent papers describing the stereoselective synthesis of γ-
amino acids. In this update, the γ-amino acids have been classified according to the type of …

Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis

S Bera, R Mao, X Hu - Nature chemistry, 2021 - nature.com
Cross-coupling of two alkyl fragments is an efficient method to produce organic molecules
rich in sp 3-hybridized carbon centres, which are attractive candidate compounds in drug …

Recent advances in photocatalytic decarboxylative coupling reactions in medicinal chemistry

L McMurray, TM McGuire, RL Howells - Synthesis, 2020 - thieme-connect.com
This review covers recent advances in decarboxylative photocatalysis applicable to the
medicinal chemist. The review is not intended to be exhaustive, but instead is focussed on …

Durch sichtbares Licht induzierte decarboxylierende Funktionalisierung von Carbonsäuren und ihren Derivaten

J Xuan, ZG Zhang, WJ Xiao - Angewandte Chemie, 2015 - Wiley Online Library
Der radikalischen decarboxylierenden Funktionalisierung von Carbonsäuren und ihren
Derivaten mithilfe von sichtbarem Licht wird seit einiger Zeit erhöhte Aufmerksamkeit zuteil …

Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids

X Tian, T Xuan, J Gao, X Zhang, T Liu, F Luo… - Nature …, 2024 - nature.com
Tetrahydro-β-carboline skeletons are prominent and ubiquitous in an extraordinary range of
indole alkaloid natural products and pharmaceutical compounds. Powerful synthetic …

Growing Utilization of Radical Chemistry in the Synthesis of Pharmaceuticals

A Gupta, JK Laha - The Chemical Record, 2023 - Wiley Online Library
Our current unhealthy lifestyle and the exponential surge in the population getting affected
by a variety of diseases have made pharmaceuticals or drugs an imperative part of life …

An alternate synthesis of appetite suppressant (R)-2-benzylmorpholine employing Sharpless asymmetric epoxidation strategy

N Viswanadh, P Mujumdar, M Sasikumar, SS Kunte… - Tetrahedron …, 2016 - Elsevier
An alternate synthesis of appetite suppressant (R)-2-benzylmorpholine employing Sharpless
asymmetric epoxidation strategy - ScienceDirect Skip to main contentSkip to article Elsevier …

A new enantioselective synthesis of the anti-Parkinson agent safinamide

A Reddi, M Mujahid, M Sasikumar… - Synthesis, 2014 - thieme-connect.com
An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from
simple, commercially available, starting materials is described. The protocol might also be …