Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …

The extracellular matrix (ECM) is the noncellular component critical in the maintenance of
organ structure and the regulation of tissue development, organ structure, and cellular …

Abstract Kallikrein-related peptidase 8 (KLK8) acts as an oncogene or anti-oncogene in
various tumours, and the abnormal expression of KLK8 is involved in the carcinogenesis of …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Increased and changed deposition of extracellular matrix proteins is a key feature of airway
wall remodeling in obstructive pulmonary diseases, including asthma and chronic …

The mechanisms of drug resistance in cancer are not fully elucidated. To study the drug
resistance of gastric cancer, we analyzed gene expression and DNA methylation profiles of …

Aberrant DNA methylation leads to abnormal gene expression, making it a significant
regulator in the progression of cancer and leading to the requirement for integration of gene …

Kallikrein gene family as biomarkers for recurrent prostate cancer Page 1 450 www.cmj.hr Aim
To assess kallikrein (KLK) expression in recurrent and non-recurrent prostate tumors and …

Purpose To develop a novel method to quantify the amount of fibrosis in the salivary gland
and to investigate the relationship between fibrosis and specific symptoms associated with …