Human pluripotent stem cells (PSCs) show epiblast-type pluripotency that is maintained with
ACTIVIN/FGF2 signaling. Here, we report the acquisition of a unique stem cell phenotype by …

Germline-competent embryonic stem cells (ESCs) have been derived from mice and rats
using culture conditions that include an inhibitor of glycogen synthase kinase 3 (GSK3) …

Embryonic stem (ES) cells are isolated from the inner cell mass of a blastocyst, and are used
for the generation of gene-modified animals. In mice, the transplantation of gene-modified …

Embryonic stem cell (ESC) pluripotency is orchestrated by distinct signaling pathways that
are often targeted to maintain ESC self-renewal or their differentiation to other lineages. We …

Rat pluripotent stem cells, embryonic stem cells (ESCs), and induced pluripotent stem cells
(iPSCs) as mouse and human ones have a great potential for studying mammalian early …

Mesenchymal stromal cells (MSCs) hold great promise in the field of regenerative medicine
due to their ability to create a variable localized anti-inflammatory effect in injuries such as …

Mesenchymal stromal cells (MSCs) are of therapeutic interest due to their
immunomodulatory and regenerative properties. As a therapeutic, MSCs have limitations …

Even though rats are popular model animals, the ultrastructure of their pluripotent cells, that
is, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), remains …

Differentiation of cell types homologous between species are controlled by conserved
networks of regulatory elements driving gene expression. In order to identify conservation of …

Background: Signaling mechanisms regulating rat embryonic stem cells (rESCs)
pluripotency are poorly understood. Results: Inhibition of protein kinase C (PKC) signaling …