Novel 1, 3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and …
AMM Shaker, MI Shahin, AM AboulMagd… - Bioorganic …, 2022 - Elsevier
Three series of novel 1-aryl-3-(4-methylsulfonylphenyl) pyrazole derivatives were
synthesized, characterized by several spectroscopic techniques, and investigated as …
synthesized, characterized by several spectroscopic techniques, and investigated as …
Pyrazolo-imidazolidinones: Synthesis, antimicrobial assessment and molecular modelling studies by molecular mechanic and quantum mechanic approach
Antimicrobial resistance (AMR) and multidrug resistance (MDR) have become global
therapeutic barriers and due to this, there is increasing global mortality. To overcome …
therapeutic barriers and due to this, there is increasing global mortality. To overcome …
Design and synthesis of novel enantiopure Bis (5-Isoxazolidine) derivatives: insights into their antioxidant and antimicrobial potential via in silico drug-likeness …
ALA Arwa, M ALSaeedy, A Alrabie, I Al-Qadsy… - Heliyon, 2022 - cell.com
A series of novel compounds, mono-5-isoxazolidines, and bis (5-isoxazolidines) derivatives,
were prepared as bicycloadducts. The new series of isoxazolidines were designed and …
were prepared as bicycloadducts. The new series of isoxazolidines were designed and …
Methanesulfonamide derivatives as gastric safe anti-inflammatory agents: Design, synthesis, selective COX-2 inhibitory activity, histopathological and histochemical …
EKA Abdelall, LS Aboelnaga, RM Hassan… - Bioorganic Chemistry, 2023 - Elsevier
Novel chalcone 3a-c, pyrazoline 4a-i and pyridine 5a-c, 6a&b derivatives bearing
methanesulfonamide moiety were synthesized. Their construction was confirmed using …
methanesulfonamide moiety were synthesized. Their construction was confirmed using …
Drug discovery of new anti-inflammatory compounds by targeting cyclooxygenases
S Burayk, K Oh-Hashi, M Kandeel - Pharmaceuticals, 2022 - mdpi.com
The goal of achieving anti-inflammatory efficacy with the fewest possible adverse effects
through selective COX-2 inhibition is still being investigated in order to develop drugs with …
through selective COX-2 inhibition is still being investigated in order to develop drugs with …
Docking, ADMET prediction, DFT analysis, synthesis, cytotoxicity, antibacterial screening and QSAR analysis of diarylpyrimidine derivatives
VK Singh, H Chaurasia, R Mishra, R Srivastava… - Journal of Molecular …, 2022 - Elsevier
A new series of 2, 4 disubstituted diarylpyrimidine derivatives has been designed,
synthesized and screened for their antibacterial activity. QSAR studies followed by …
synthesized and screened for their antibacterial activity. QSAR studies followed by …
Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1, 4-diaryl-1, 2, 3-triazole neolignan-celecoxib hybrids
JL Felipe, TB Cassamale, LD Lourenco… - Bioorganic …, 2022 - Elsevier
This study reports the synthesis of novel neolignans-celecoxib hybrids and the evaluation of
their biological activity. Analogs 8–13 (L13-L18) exhibited anti-inflammatory activity …
their biological activity. Analogs 8–13 (L13-L18) exhibited anti-inflammatory activity …
Enhanced synthesis of novel multisubstituted isoxazolidines as potential antimicrobial and antioxidant agents using zinc (II) catalyst, and in silico studies
A Al-Adhreai, M ALSaeedy, A Alrabie… - Journal of Molecular …, 2023 - Elsevier
In the effort of our endeavour to synthesize new heterocyclic bioactive agents, we succeed
the synthesis of a new series of Multisubstituted isoxazolidines (3-(4-substituted)-5-(1H …
the synthesis of a new series of Multisubstituted isoxazolidines (3-(4-substituted)-5-(1H …
In vitro, in vivo and in silico evaluation of analgesic, anti-inflammatory, and anti-pyretic activity of salicylate rich fraction from Gaultheria trichophylla Royle (Ericaceae)
Ethnopharmacological relevance Medicinal properties of Gaultheria have been used in
traditional medicine to treat pain and inflammation. Aim of the study Hence, the purpose of …
traditional medicine to treat pain and inflammation. Aim of the study Hence, the purpose of …
Biologically important alumina nanoparticles modified polyvinylpyrrolidone scaffolds in vitro characterizations and it is in vivo wound healing efficacy
SB Balakrishnan, S Kuppu, S Thambusamy - Journal of Molecular Structure, 2021 - Elsevier
Recently, ceramics have been enormously using for drug delivery applications. Alumina (Al
2 O 3) is a common ceramic material, offering enhanced reliability and excellent …
2 O 3) is a common ceramic material, offering enhanced reliability and excellent …