Approximately 10% of all pathological mutations are nonsense mutations that are
responsible for several severe genetic diseases for which no treatment regimens are …

Neurodegenerative diseases are severely debilitating conditions characterized primarily by
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …

Allosteric regulation, induced by perturbations at an allosteric site topographically distinct
from the orthosteric site, is one of the most direct and efficient ways to fine-tune …

Introduction Molecular docking has been consolidated as one of the most important methods
in the molecular modeling field. It has been recognized as a prominent tool in the study of …

A variety of glycan structures cover the surface of all cells and are involved in myriad
biological processes, including but not limited to, cell adhesion and communication, protein …

To date, the COVID-19 pandemic has claimed over 1 million human lives, infected another
50 million individuals and wreaked havoc on the global economy. The crisis has spurred the …

A bright spot in the SARS‐CoV‐2 (CoV‐2) coronavirus pandemic has been the immediate
mobilization of the biomedical community, working to develop treatments and vaccines for …

Fragment‐based drug discovery (FBDD) has become an established approach for the
generation of early lead candidates. However, despite its success and inherent advantages …

Small molecule modulators of protein–protein interactions (PPIs) are being pursued as
novel anticancer, antiviral and antimicrobial drug candidates. We have utilized a large data …

The human intestines are colonized by trillions of microbes, comprising the gut microbiota,
which produce diverse small molecule metabolites and modify host metabolites, such as bile …